David L Eaton
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Explore the profile of David L Eaton including associated specialties, affiliations and a list of published articles.
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Articles
47
Citations
966
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Recent Articles
1.
Eaton D, Williams D, Coulombe R
Toxins (Basel)
. 2025 Jan;
17(1).
PMID: 39852983
It has been known since the early days of the discovery of aflatoxin B1 (AFB1) that there were large species differences in susceptibility to AFB1. It was also evident early...
2.
Kensler T, Eaton D
Toxins (Basel)
. 2024 Nov;
16(11).
PMID: 39591251
Aflatoxins are mycotoxins produced by and several other related organisms and are common contaminants of numerous grains and nuts, especially maize (corn) and peanuts. Although, undoubtedly, aflatoxins have been present...
3.
Eaton D, Simon T, Kaminski N, Perdew G, Nebert D
Regul Toxicol Pharmacol
. 2024 Mar;
149:105598.
PMID: 38548044
In 2022 the World Health Organization (WHO) published updated 'Toxic Equivalence Factors' (TEFs) for a wide variety of chlorinated dioxins, dibenzofurans and PCBs [collectively referred to as 'dioxin-like chemicals'; DLCs)...
4.
Eaton D, Simon T, Kaminski N, Perdew G, Nebert D
Regul Toxicol Pharmacol
. 2024 Mar;
149:105599.
PMID: 38490576
No abstract available.
5.
Kwan L, Eaton D, Andersen S, Dow-Edwards D, Levin E, Talpos J, et al.
Neurotoxicol Teratol
. 2020 Jul;
81:106916.
PMID: 32698050
Response variability across the lifespan is an important consideration in toxicology and risk assessment, and the toxic effects of drugs and chemicals during adolescence need more research. This paper summarizes...
6.
St Helen G, Eaton D
JAMA Intern Med
. 2018 May;
178(7):984-986.
PMID: 29801158
No abstract available.
7.
Chang S, Weber E, Sidorenko V, Chapron A, Yeung C, Gao C, et al.
JCI Insight
. 2017 Dec;
2(22).
PMID: 29202460
Environmental exposures pose a significant threat to human health. However, it is often difficult to study toxicological mechanisms in human subjects due to ethical concerns. Plant-derived aristolochic acids are among...
8.
Van Ness K, Chang S, Weber E, Zumpano D, Eaton D, Kelly E
Curr Protoc Toxicol
. 2017 Aug;
73:14.18.1-14.18.28.
PMID: 28777442
The liver and the kidney are key toxicity target organs during drug development campaigns, as they typically carry the burden of drug transport and metabolism. Primary hepatocytes and proximal tubule...
9.
Chang S, Voellinger J, Van Ness K, Chapron B, Shaffer R, Neumann T, et al.
Toxicol In Vitro
. 2017 Jan;
40:170-183.
PMID: 28089783
The liver is the main site for drug and xenobiotics metabolism, including inactivation or bioactivation. In order to improve the predictability of drug safety and efficacy in clinical development, and...
10.
Cook T, Hoekstra J, Eaton D, Zhang J
Brain Pathol
. 2015 Jun;
26(1):75-81.
PMID: 26095919
Mortalin, an essential mitochondrial chaperone protein, has previously been implicated in the pathogenesis of a wide array of diseases, including neurodegenerative conditions such as Parkinson's disease (PD) and Alzheimer's disease....