David Kerk
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Explore the profile of David Kerk including associated specialties, affiliations and a list of published articles.
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16
Citations
461
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Recent Articles
1.
Kerk D, White-Gloria C, Johnson J, Moorhead G
Biosci Rep
. 2023 May;
PMID: 37144562
Phosphoprotein phosphatases (PPPs) are a ubiquitous class of enzymes which dephosphorylate serine and threonine residues on substrate proteins involved in a wide variety of cellular processes. The active site of...
2.
Kerk D, Valdes-Tresanco M, Toth R, Noskov S, Ng K, Moorhead G
BBA Adv
. 2023 Apr;
1:100005.
PMID: 37082010
Background: Phosphoprotein phosphatases (PPP) belong to the PPP Sequence family, which in turn belongs to the broader metallophosphoesterase (MPE) superfamily. The relationship between the PPP Sequence family and other members...
3.
Kerk D, Mattice J, Valdes-Tresanco M, Noskov S, Ng K, Moorhead G
Sci Rep
. 2021 Jul;
11(1):13681.
PMID: 34211082
Phosphoprotein phosphatase (PPP) enzymes are ubiquitous proteins involved in cellular signaling pathways and other functions. Here we have traced the origin of the PPP sequences of Eukaryotes and their radiation....
4.
Kerk D, Silver D, Uhrig R, Moorhead G
PLoS One
. 2015 Aug;
10(8):e0132863.
PMID: 26241330
Mg+2/Mn+2-dependent type 2C protein phosphatases (PP2Cs) are ubiquitous in eukaryotes, mediating diverse cellular signaling processes through metal ion catalyzed dephosphorylation of target proteins. We have identified a distinct PP2C sequence...
5.
Labandera A, Vahab A, Chaudhuri S, Kerk D, Moorhead G
Biochem Biophys Res Commun
. 2015 Feb;
458(4):739-44.
PMID: 25666948
Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase of eukaryotes. PP2A containing the B55 subunit is a key regulator of mitosis and must be inhibited by phosphorylated α-endosulfine (ENSA)...
6.
Kerk D, Uhrig R, Moorhead G
Plant Signal Behav
. 2014 Mar;
8(12):e27365.
PMID: 24675170
Reversible phosphorylation is a widespread modification affecting the great majority of eukaryotic cellular proteins, and whose effects influence nearly every cellular function. Protein phosphatases are increasingly recognized as exquisitely regulated...
7.
Uhrig R, Kerk D, Moorhead G
Plant Physiol
. 2013 Oct;
163(4):1829-43.
PMID: 24108212
Protein phosphorylation is a reversible regulatory process catalyzed by the opposing reactions of protein kinases and phosphatases, which are central to the proper functioning of the cell. Dysfunction of members...
8.
Magnuson T, Swenson M, Paszczynski A, Deobald L, Kerk D, Cummings D
Biometals
. 2010 Jul;
23(6):1129-38.
PMID: 20593301
Acidiphilium cryptum JF-5, an acidophilic iron-respiring Alphaproteobacterium, has the ability to reduce chromate under aerobic and anaerobic conditions, making it an intriguing and useful model organism for the study of...
9.
Kerk D, Moorhead G
BMC Evol Biol
. 2010 Jun;
10:196.
PMID: 20576132
Background: Phosphorylated phosphatidylinositol (PtdIns) lipids, produced and modified by PtdIns kinases and phosphatases, are critical to the regulation of diverse cellular functions. The myotubularin PtdIns-phosphate phosphatases have been well characterized...
10.
Moorhead G, De Wever V, Templeton G, Kerk D
Biochem J
. 2008 Dec;
417(2):401-9.
PMID: 19099538
Protein phosphorylation appears to be a universal mechanism of protein regulation. Genomics has provided the means to compile inventories of protein phosphatases across a wide selection of organisms and this...