David J Witherspoon
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Explore the profile of David J Witherspoon including associated specialties, affiliations and a list of published articles.
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30
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1453
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Recent Articles
1.
Feusier J, Watkins W, Thomas J, Farrell A, Witherspoon D, Baird L, et al.
Genome Res
. 2019 Oct;
29(10):1567-1577.
PMID: 31575651
Germline mutation rates in humans have been estimated for a variety of mutation types, including single-nucleotide and large structural variants. Here, we directly measure the germline retrotransposition rate for the...
2.
Feusier J, Witherspoon D, Watkins W, Goubert C, Sasani T, Jorde L
Mob DNA
. 2017 Aug;
8:9.
PMID: 28770012
Background: Polymorphic human elements are excellent tools for assessing population structure, and new retrotransposition events can contribute to disease. Next-generation sequencing has greatly increased the potential to discover elements in...
3.
Staples J, Witherspoon D, Jorde L, Nickerson D, Below J, Huff C
Am J Hum Genet
. 2016 Jul;
99(1):154-62.
PMID: 27374771
Accurate estimation of shared ancestry is an important component of many genetic studies; current prediction tools accurately estimate pairwise genetic relationships up to the ninth degree. Pedigree-aware distant-relationship estimation (PADRE)...
4.
Platt 2nd R, Zhang Y, Witherspoon D, Xing J, Suh A, Keith M, et al.
Genome Biol Evol
. 2015 May;
7(6):1664-75.
PMID: 26014613
Identification of retrotransposon insertions in nonmodel taxa can be technically challenging and costly. This has inhibited progress in understanding retrotransposon insertion dynamics outside of a few well-studied species. To address...
5.
Wu W, Witherspoon D, Fraser A, Clark E, Rogers A, Stoddard G, et al.
Hum Genet
. 2015 Apr;
134(7):803-8.
PMID: 25920518
Preterm birth (PTB), defined as birth prior to a gestational age (GA) of 37 completed weeks, affects more than 10% of births worldwide. PTB is the leading cause of neonatal...
6.
Shared and unique signals of high-altitude adaptation in geographically distinct Tibetan populations
Wuren T, Simonson T, Qin G, Xing J, Huff C, Witherspoon D, et al.
PLoS One
. 2014 Mar;
9(3):e88252.
PMID: 24642866
Recent studies have used a variety of analytical methods to identify genes targeted by selection in high-altitude populations located throughout the Tibetan Plateau. Despite differences in analytic strategies and sample...
7.
Xing J, Wuren T, Simonson T, Watkins W, Witherspoon D, Wu W, et al.
PLoS Genet
. 2013 Jul;
9(7):e1003634.
PMID: 23874230
Deedu (DU) Mongolians, who migrated from the Mongolian steppes to the Qinghai-Tibetan Plateau approximately 500 years ago, are challenged by environmental conditions similar to native Tibetan highlanders. Identification of adaptive...
8.
Witherspoon D, Zhang Y, Xing J, Watkins W, Ha H, Batzer M, et al.
Genome Res
. 2013 Apr;
23(7):1170-81.
PMID: 23599355
Alu retrotransposons are the most numerous and active mobile elements in humans, causing genetic disease and creating genomic diversity. Mobile element scanning (ME-Scan) enables comprehensive and affordable identification of mobile...
9.
Xing J, Witherspoon D, Jorde L
Trends Genet
. 2013 Jan;
29(5):280-9.
PMID: 23312846
Mobile elements comprise more than half of the human genome, but until recently their large-scale detection was time consuming and challenging. With the development of new high-throughput sequencing (HTS) technologies,...
10.
Watkins W, Xing J, Huff C, Witherspoon D, Zhang Y, Perego U, et al.
BMC Genet
. 2012 May;
13:39.
PMID: 22606979
Background: Populations of the Americas were founded by early migrants from Asia, and some have experienced recent genetic admixture. To better characterize the native and non-native ancestry components in populations...