David J R Fulton
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Explore the profile of David J R Fulton including associated specialties, affiliations and a list of published articles.
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72
Citations
1784
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Recent Articles
1.
Batori R, Bordan Z, Padgett C, Huo Y, Chen F, Atawia R, et al.
Antioxidants (Basel)
. 2025 Feb;
14(2).
PMID: 40002359
Obesity and type 2 diabetes (T2D) increase cardiovascular risk, largely due to altered metabolic state. An early consequence of T2D/obesity is the loss of endothelial function and impaired nitric oxide...
2.
Romero M, Yue Q, Ahn W, Hamacher J, Zaidi Y, Haigh S, et al.
Am J Respir Cell Mol Biol
. 2024 Oct;
PMID: 39405473
Infection of lung endothelial cells with pneumococci activates the superoxide-generating enzyme NADPH oxidase 2 (NOX2), involving the pneumococcal virulence factor pneumolysin (PLY). Excessive NOX2 activity disturbs capillary barriers, but its...
3.
Liu T, Yuan J, Dai C, Chen M, Fan J, Humphreys B, et al.
Am J Physiol Cell Physiol
. 2024 Sep;
327(4):C1094-C1110.
PMID: 39250817
The class 3 phosphatidylinositol 3-kinase (Pik3c3) plays critical roles in regulating autophagy, endocytosis, and nutrient sensing, but its expression profile in the kidney remains undefined. Recently, we validated a Pik3c3...
4.
Su Y, Lucas R, Fulton D, Verin A
Chin Med J Pulm Crit Care Med
. 2024 Jul;
2(2):80-87.
PMID: 39006829
Endothelial cells (ECs) form a semi-permeable barrier between the interior space of blood vessels and the underlying tissues. Pulmonary endothelial barrier integrity is maintained through coordinated cellular processes involving receptors,...
5.
Wang W, Li E, Zou J, Qu C, Ayala J, Wen Y, et al.
Circ Res
. 2024 Jun;
135(3):e39-e56.
PMID: 38873758
Background: Clearance of damaged mitochondria via mitophagy is crucial for cellular homeostasis. Apart from Parkin, little is known about additional Ub (ubiquitin) ligases that mediate mitochondrial ubiquitination and turnover, particularly...
6.
Bordan Z, Batori R, Haigh S, Li X, Meadows M, Brown Z, et al.
Circulation
. 2024 Apr;
150(5):393-410.
PMID: 38682326
Background: Pulmonary arterial hypertension (PAH) is high blood pressure in the lungs that originates from structural changes in small resistance arteries. A defining feature of PAH is the inappropriate remodeling...
7.
Patil R, Maloney M, Lucas R, Fulton D, Patel V, Bagi Z, et al.
Biomolecules
. 2024 Feb;
14(2).
PMID: 38397377
A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and, as such, provides a semi-selective barrier between the blood and the interstitial space. Compromise of the lung...
8.
Zaidi S, Xu Z, Lemtalsi T, Sandow P, Athota S, Liu F, et al.
Cell Death Dis
. 2023 Oct;
14(10):661.
PMID: 37816735
We previously found that global deletion of the mitochondrial enzyme arginase 2 (A2) limits optic nerve crush (ONC)-induced neuronal death. Herein, we examined the cell-specific role of A2 in this...
9.
Haigh S, Brown Z, Shivers M, Sellers H, West M, Barman S, et al.
Antioxidants (Basel)
. 2023 Sep;
12(9).
PMID: 37759992
The detection of superoxide anion (O) in biological tissues remains challenging. Barriers to convenient and reproducible measurements include expensive equipment, custom probes, and the need for high sensitivity and specificity....
10.
Atawia R, Batori R, Jordan C, Kennard S, Antonova G, Bruder-Nascimento T, et al.
Hypertension
. 2023 Sep;
80(10):2059-2071.
PMID: 37729634
Background: Type 1 diabetes (T1D) is a major cause of endothelial dysfunction. Although cellular bioenergetics has been identified as a new regulator of vascular function, whether glycolysis, the primary bioenergetic...