David J Huggins
Overview
Explore the profile of David J Huggins including associated specialties, affiliations and a list of published articles.
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Articles
63
Citations
902
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0
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Recent Articles
1.
Meyer C, Garzia A, Miller M, Huggins D, Myers R, Hoffmann H, et al.
Nature
. 2024 Dec;
637(8048):1178-1185.
PMID: 39663451
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The rapid development of highly effective vaccines against SARS-CoV-2 has altered the trajectory of the pandemic,...
2.
Huggins D, Baell J, Brennan P, Burgin A, Scott D
Nat Rev Drug Discov
. 2024 Sep;
PMID: 39327502
No abstract available.
3.
Heinzelmann G, Huggins D, Gilson M
J Chem Theory Comput
. 2024 Sep;
20(19):8740.
PMID: 39286862
No abstract available.
4.
Heinzelmann G, Huggins D, Gilson M
J Chem Theory Comput
. 2024 Aug;
20(15):6518-6530.
PMID: 39088306
Absolute binding free energy (ABFE) calculations with all-atom molecular dynamics (MD) have the potential to greatly reduce costs in the first stages of drug discovery. Here, we introduce BAT2, the...
5.
Sun S, Ginn J, Kochanczyk T, Arango N, Jiang X, Huggins D, et al.
Angew Chem Int Ed Engl
. 2024 Jul;
63(44):e202407276.
PMID: 38997232
Tuberculosis remains a leading cause of death from a single infection worldwide. Drug resistance to existing and even new antimycobacterials calls for research into novel targets and unexplored mechanisms of...
6.
Zeledon E, Baxt L, Khan T, Michino M, Miller M, Huggins D, et al.
Parasit Vectors
. 2024 Jun;
17(1):276.
PMID: 38937807
Background: Female Aedes aegypti mosquitoes can spread disease-causing pathogens when they bite humans to obtain blood nutrients required for egg production. Following a complete blood meal, host-seeking is suppressed until...
7.
Michino M, Khan T, Miller M, Fukase Y, Vendome J, Adura C, et al.
ACS Med Chem Lett
. 2024 Apr;
15(4):524-532.
PMID: 38628784
Eleven-nineteen leukemia (ENL) is an epigenetic reader protein that drives oncogenic transcriptional programs in acute myeloid leukemia (AML). AML is one of the deadliest hematopoietic malignancies, with an overall 5-year...
8.
Zeledon E, Baxt L, Khan T, Michino M, Miller M, Huggins D, et al.
bioRxiv
. 2024 Mar;
PMID: 38464241
Female mosquitoes can spread disease-causing pathogens when they bite humans to obtain blood nutrients required for egg production. Following a complete blood meal, host-seeking is suppressed until eggs are laid....
9.
Sun S, Fushimi M, Rossetti T, Kaur N, Ferreira J, Miller M, et al.
J Chem Inf Model
. 2024 Jan;
64(3):1106.
PMID: 38258980
No abstract available.
10.
Michino M, Beautrait A, Boyles N, Nadupalli A, Dementiev A, Sun S, et al.
ACS Bio Med Chem Au
. 2023 Dec;
3(6):507-515.
PMID: 38144256
Lpd (lipoamide dehydrogenase) in (Mtb) is required for virulence and is a genetically validated tuberculosis (TB) target. Numerous screens have been performed over the last decade, yet only two inhibitor...