David J Hardee
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Explore the profile of David J Hardee including associated specialties, affiliations and a list of published articles.
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5
Citations
68
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Recent Articles
1.
Ng T, Correia I, Seagal J, Degoey D, Schrimpf M, Hardee D, et al.
Viruses
. 2022 May;
14(5).
PMID: 35632703
The coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a recently emerged human coronavirus. COVID-19 vaccines have proven to be successful in...
2.
Sharland J, Wei B, Hardee D, Hodges T, Gong W, Voight E, et al.
Chem Sci
. 2021 Sep;
12(33):11181-11190.
PMID: 34522315
This study describes general methods for the enantioselective syntheses of pharmaceutically relevant 1-aryl-2-heteroaryl- and 1,2-diheteroarylcyclopropane-1-carboxylates through dirhodium tetracarboxylate-catalysed asymmetric cyclopropanation of vinyl heterocycles with aryl- or heteroaryldiazoacetates. The reactions are...
3.
Turek A, Hardee D, Ullman A, Nocera D, Jacobsen E
Angew Chem Int Ed Engl
. 2015 Nov;
55(2):539-44.
PMID: 26612607
Quinones are important organic oxidants in a variety of synthetic and biological contexts, and they are susceptible to activation towards electron transfer through hydrogen bonding. Whereas this effect of hydrogen...
4.
Hardee D, Kovalchuke L, Lambert T
J Am Chem Soc
. 2010 Mar;
132(14):5002-3.
PMID: 20297823
The first example of aromatic cation-activated nucleophilic acyl substitution has been achieved. The conversion of carboxylic acids to their corresponding acid chlorides occurs rapidly in the presence of 3,3-dichlorocyclopropenes via...
5.
Hardee D, Lambert T
J Am Chem Soc
. 2009 Jun;
131(22):7536-7.
PMID: 19489639
A new method for cyclopropanation involving intramolecular methylene transfer from an epoxide to an olefin has been developed. This La(OTf)(3)-catalyzed process proceeds with good efficiency and with high stereoselectivity. A...