David Hollingworth
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Explore the profile of David Hollingworth including associated specialties, affiliations and a list of published articles.
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20
Citations
610
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Recent Articles
1.
Hollingworth D, Herold K, Kelly G, Mykhaylyk V, Xiang J, Zhang D, et al.
bioRxiv
. 2024 Nov;
PMID: 39574657
Volatile general anesthetics are used for inhalational anesthesia in hundreds of millions of surgical procedures annually, yet their mechanisms of action remain unclear. Membrane proteins involved in cell signaling are...
2.
Hollingworth D, Thomas F, Page D, Fouda M, Lopez-Rios de Castro R, Sula A, et al.
Nat Commun
. 2024 Sep;
15(1):8426.
PMID: 39341837
Neuronal hyperexcitability is a key element of many neurodegenerative disorders including the motor neuron disease Amyotrophic Lateral Sclerosis (ALS), where it occurs associated with elevated late sodium current (I). I...
3.
Sula A, Hollingworth D, Ng L, Larmore M, DeCaen P, Wallace B
Mol Cell
. 2021 Jan;
81(6):1160-1169.e5.
PMID: 33503406
Voltage-gated sodium channels are targets for many analgesic and antiepileptic drugs whose therapeutic mechanisms and binding sites have been well characterized. We describe the identification of a previously unidentified receptor...
4.
Sait L, Sula A, Ghovanloo M, Hollingworth D, Ruben P, Wallace B
Elife
. 2020 Oct;
9.
PMID: 33089780
Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved...
5.
Nicastro G, Candel A, Uhl M, Oregioni A, Hollingworth D, Backofen R, et al.
Cell Rep
. 2017 Feb;
18(5):1187-1199.
PMID: 28147274
Zipcode binding protein 1 (ZBP1) is an oncofetal RNA-binding protein that mediates the transport and local translation of β-actin mRNA by the KH3-KH4 di-domain, which is essential for neuronal development....
6.
Nicastro G, Garcia-Mayoral M, Hollingworth D, Kelly G, Martin S, Briata P, et al.
Nat Struct Mol Biol
. 2012 Nov;
19(12):1282-6.
PMID: 23142982
Let-7 is an important tumor-suppressive microRNA (miRNA) that acts as an on-off switch for cellular differentiation and regulates the expression of a set of human oncogenes. Binding of the human...
7.
Hollingworth D, Candel A, Nicastro G, Martin S, Briata P, Gherzi R, et al.
Nucleic Acids Res
. 2012 May;
40(14):6873-86.
PMID: 22547390
In eukaryotes, RNA-binding proteins that contain multiple K homology (KH) domains play a key role in coordinating the different steps of RNA synthesis, metabolism and localization. Understanding how the different...
8.
Cukier C, Hollingworth D, Martin S, Kelly G, Diaz-Moreno I, Ramos A
Nat Struct Mol Biol
. 2010 Aug;
17(9):1058-64.
PMID: 20711187
The far upstream element (FUSE) regulatory system promotes a peak in the concentration of c-Myc during cell cycle. First, the FBP transcriptional activator binds to the FUSE DNA element upstream...
9.
Diaz-Moreno I, Hollingworth D, Kelly G, Martin S, Garcia-Mayoral M, Briata P, et al.
Nucleic Acids Res
. 2010 Apr;
38(15):5193-205.
PMID: 20385598
KSRP is a multi-domain RNA-binding protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding for cellular proliferation and inflammatory response factors. The selectivity of this mRNA degradation mechanism...
10.
Diaz-Moreno I, Hollingworth D, Frenkiel T, Kelly G, Martin S, Howell S, et al.
Nat Struct Mol Biol
. 2009 Feb;
16(3):238-46.
PMID: 19198587
The AU-rich element (ARE)-mediated mRNA-degradation activity of the RNA binding K-homology splicing regulator protein (KSRP) is regulated by phosphorylation of a serine within its N-terminal KH domain (KH1). In the...