David G Ashbrook
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Explore the profile of David G Ashbrook including associated specialties, affiliations and a list of published articles.
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35
Citations
793
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Recent Articles
1.
Rajan J, Gill K, Chow E, Ashbrook D, Williams R, Zwicker J, et al.
Genes Brain Behav
. 2025 Mar;
24(2):e70014.
PMID: 40071748
The fundamental skills for motor coordination and motor control emerge through development. Neurodevelopmental disorders such as developmental coordination disorder (DCD) lead to impaired acquisition of motor skills. This study investigated...
2.
Garrison E, Guarracino A, Heumos S, Villani F, Bao Z, Tattini L, et al.
Nat Methods
. 2024 Oct;
21(11):2008-2012.
PMID: 39433878
Pangenome graphs can represent all variation between multiple reference genomes, but current approaches to build them exclude complex sequences or are based upon a single reference. In response, we developed...
3.
Ball R, Bogue M, Liang H, Srivastava A, Ashbrook D, Lamoureux A, et al.
Genome Res
. 2024 Jan;
34(1):145-159.
PMID: 38290977
Hundreds of inbred mouse strains and intercross populations have been used to characterize the function of genetic variants that contribute to disease. Thousands of disease-relevant traits have been characterized in...
4.
Sullivan K, Chapman C, Lu L, Ashbrook D, Wang Y, Alduraibi F, et al.
Clin Immunol
. 2023 Nov;
257:109842.
PMID: 37981105
Cardinal features of lupus include elevated B cell activation and autoantibody production with a female sex preponderance. We quantified interactions of sex and genetic variation on the development of autoimmune...
5.
Gu Q, Orgil B, Bajpai A, Chen Y, Ashbrook D, Starlard-Davenport A, et al.
Int J Mol Sci
. 2023 Aug;
24(16).
PMID: 37628941
Background: Troponin-I interacting kinase encoded by the gene is expressed in nuclei and Z-discs of cardiomyocytes. Mutations in were identified in patients with cardiac conduction diseases, arrhythmias, and cardiomyopathy. Methods:...
6.
Ball R, Bogue M, Liang H, Srivastava A, Ashbrook D, Lamoureux A, et al.
bioRxiv
. 2023 Aug;
PMID: 37609331
Hundreds of inbred laboratory mouse strains and intercross populations have been used to functionalize genetic variants that contribute to disease. Thousands of disease relevant traits have been characterized in mice...
7.
Gill K, Rajan J, Chow E, Ashbrook D, Williams R, Zwicker J, et al.
Genes Brain Behav
. 2023 Aug;
22(6):e12859.
PMID: 37553802
Developmental Coordination Disorder (DCD) is a neurodevelopmental disorder of unknown etiology that affects one in 20 children. There is an indication that DCD has an underlying genetic component due to...
8.
Meade R, Long J, Jinich A, Rhee K, Ashbrook D, Williams R, et al.
G3 (Bethesda)
. 2023 Jul;
13(9).
PMID: 37405387
Genetic differences among mammalian hosts and among strains of Mycobacterium tuberculosis (Mtb) are well-established determinants of tuberculosis (TB) patient outcomes. The advent of recombinant inbred mouse panels and next-generation transposon...
9.
Mozhui K, OCallaghan J, Ashbrook D, Prins P, Zhao W, Lu L, et al.
Front Toxicol
. 2023 Jun;
5:1162749.
PMID: 37389175
Of the nearly 1 million military personnel who participated in the 1990-1991 Gulf War, between 25% and 35% became ill with what now is referred to as Gulf War Illness...
10.
Maksimov M, Wu C, Ashbrook D, Villani F, Colonna V, Mousavi N, et al.
Genome Res
. 2023 May;
33(5):689-702.
PMID: 37127331
Short tandem repeats (STRs) are a class of rapidly mutating genetic elements typically characterized by repeated units of 1-6 bp. We leveraged whole-genome sequencing data for 152 recombinant inbred (RI)...