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David Frame

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Articles 31
Citations 504
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Recent Articles
1.
Bajwa A, Zhao Q, Geer M, Lin C, Westholder J, Maakaron J, et al.
Blood Adv . 2024 Oct; 9(1):170-175. PMID: 39437770
Chimeric antigen receptor T-cell (CAR-T) therapies are effective in many hematologic malignancies; however, adverse events including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) can affect a...
2.
Michniacki T, Walkovich K, DeMeyer L, Saad N, Hannibal M, Basiaga M, et al.
J Clin Immunol . 2022 Aug; 42(8):1766-1777. PMID: 35976468
Haploinsufficiency of suppressor of cytokine signaling 1 (SOCS1) is a recently discovered autoinflammatory disorder with significant rheumatologic, immunologic, and hematologic manifestations. Here we report a case of SOCS1 haploinsufficiency in...
3.
Blase J, Frame D, Michniacki T, Walkovich K
Front Immunol . 2022 May; 13:863177. PMID: 35514985
Management of refractory immune thrombocytopenia frequently involves rituximab, a chimeric anti-CD20 monoclonal antibody, to target B cells and induce remission in most patients. However, neutralizing antibodies to rituximab that nullify...
4.
Frame D, Scappaticci G, Braun T, Maliarik M, Sisson T, Pipe S, et al.
Chest . 2022 Apr; 162(2):346-355. PMID: 35413279
Background: SARS-CoV-2-related ARDS is associated with endothelial dysfunction and profound dysregulation of the thrombotic-fibrinolytic pathway. Defibrotide is a polyanionic compound with fibrinolytic, antithrombotic, and antiinflammatory properties. Research Question: What is...
5.
Pasternak A, Marcath L, Li Y, Nguyen V, Gersch C, Rae J, et al.
Transplant Cell Ther . 2021 Sep; 28(1):19.e1-19.e7. PMID: 34583027
CYP3A5 and CYP3A4 are the predominant enzymes responsible for tacrolimus metabolism; however only a proportion of the population expresses CYP3A5 secondary to genetic variation. CYP3A5 is expressed in both the...
6.
Connelly J, Chong H, Esbenshade A, Frame D, Failing C, Secord E, et al.
Pediatr Clin North Am . 2021 Sep; 68(5):1029-1054. PMID: 34538297
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7.
Homan M, Reid J, Nachar V, Benitez L, Brown A, Kraft S, et al.
Support Care Cancer . 2021 Apr; 29(11):6505-6510. PMID: 33905012
Introduction: Nausea, vomiting, constipation, and diarrhea are common cancer and cancer therapy adverse effects. Pharmacists are uniquely positioned to optimize patient symptom control and minimize excess use of hospital resources,...
8.
Chakrabarti K, Frame D, Al Abbas M, McCune W
Curr Opin Rheumatol . 2021 Mar; 33(3):221-232. PMID: 33741807
Purpose Of Review: Although mycophenolate mofetil (MMF) has been used successfully to treat a myriad of autoimmune diseases, its complex pharmacokinetics make it difficult to determine the true drug exposure...
9.
Lynch J, Cain M, Frame D, Pierrehumbert R
Front Sustain Food Syst . 2021 Mar; 4:518039. PMID: 33644695
Agriculture is a significant contributor to anthropogenic global warming, and reducing agricultural emissions-largely methane and nitrous oxide-could play a significant role in climate change mitigation. However, there are important differences...
10.
Hough S, McDevitt R, Nachar V, Kraft S, Brown A, Christen C, et al.
JCO Oncol Pract . 2021 Feb; 17(9):e1303-e1310. PMID: 33534634
Purpose: Chemotherapy-induced nausea and vomiting (CINV) is a common cause of unplanned healthcare utilization. The University of Michigan Rogel Cancer Center initiated the chemotherapy remote care monitoring program (CRCMP) to...