David Filpula
Overview
Explore the profile of David Filpula including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
11
Citations
300
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Greenberger L, Horak I, Filpula D, Sapra P, Westergaard M, Frydenlund H, et al.
Mol Cancer Ther
. 2008 Nov;
7(11):3598-608.
PMID: 18974394
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a critical role in angiogenesis, survival, metastasis, drug resistance, and glucose metabolism. Elevated expression of the alpha-subunit of HIF-1 (HIF-1alpha), which...
2.
Filpula D, Zhao H
Adv Drug Deliv Rev
. 2007 Sep;
60(1):29-49.
PMID: 17884239
Releasable PEGylation employs customized linkers that reversibly tether a therapeutic moiety with polyethylene glycol polymers. The choice of releasable PEG linkers may have numerous applications that are insufficiently addressed by...
3.
Filpula D
Biomol Eng
. 2007 May;
24(2):201-15.
PMID: 17466589
Antibody engineering has become a well-developed discipline, encompassing discovery methods, production strategies, and modification techniques that have brought forth clinically investigated and marketed therapeutics. The realization of the long-standing goal...
4.
Filpula D, Yang K, Basu A, Hassan R, Xiang L, Zhang Z, et al.
Bioconjug Chem
. 2007 Mar;
18(3):773-84.
PMID: 17346030
Recombinant immunotoxins exhibit targeting and cytotoxic functions needed for cell-specific destruction. However, antitumor efficacy, safety, and pharmacokinetics of these therapeutics might be improved by further macromolecular engineering. SS1P is a...
5.
Wang M, Basu A, Palm T, Hua J, Youngster S, Hwang L, et al.
Bioconjug Chem
. 2006 Nov;
17(6):1447-59.
PMID: 17105223
Arginine is an important metabolite in the normal function of several biological systems, and arginine deprivation has been investigated in animal models and human clinical trials for its effects on...
6.
Krinner E, Hepp J, Hoffmann P, Bruckmaier S, Petersen L, Petsch S, et al.
Protein Eng Des Sel
. 2006 Jul;
19(10):461-70.
PMID: 16868004
GM-CSF (granulocyte-macrophage colony stimulating factor) plays a central role in inflammatory processes. Treatment with antibodies neutralizing murine GM-CSF showed significant therapeutic effects in mouse models of inflammatory diseases. We constructed...
7.
Basu A, Yang K, Wang M, Liu S, Chintala R, Palm T, et al.
Bioconjug Chem
. 2006 May;
17(3):618-30.
PMID: 16704199
Recombinant interferon-beta-1b (IFN-beta-1b) is used clinically in the treatment of multiple sclerosis. In common with many biological ligands, IFN-beta-1b exhibits a relatively short serum half-life, and bioavailability may be further...
8.
Zhao H, Yang K, Martinez A, Basu A, Chintala R, Liu H, et al.
Bioconjug Chem
. 2006 Mar;
17(2):341-51.
PMID: 16536464
The utility of PEGylation for improving therapeutic protein pharmacology would be substantially expanded if the authentic protein drugs could be regenerated in vivo. Diminution of kinetic constants of both enzymes...
9.
Yu D, Peng P, Dharap S, Wang Y, Mehlig M, Chandna P, et al.
J Control Release
. 2005 Nov;
110(1):90-102.
PMID: 16271793
Antitumor effect of poly(ethylene glycol)-camptothecin conjugate (PEG-CPT) was studied in the nude mouse model of human colon cancer xenografts. The animals were treated intravenously with 15 mg/kg of camptothecin (CPT)...
10.
Yang K, Basu A, Wang M, Chintala R, Hsieh M, Liu S, et al.
Protein Eng
. 2003 Nov;
16(10):761-70.
PMID: 14600206
The utility of single-chain Fv proteins as therapeutic agents would be realized if the circulating lives of these minimal antigen-binding polypeptides could be both prolonged and adjustable. We have developed...