David F Horrobin
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Explore the profile of David F Horrobin including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
653
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Recent Articles
1.
Macdonald D, Boyle R, Glen A, Leslie C, Glen A, Horrobin D
Prostaglandins Leukot Essent Fatty Acids
. 2014 Dec;
94:43-8.
PMID: 25547672
An immunoassay for IVA phospholipase A2 in human red blood cells is described. The assay is a non-competitive sandwich assay in which increasing amounts of the measured protein produce increased...
2.
Song C, Manku M, Horrobin D
J Nutr
. 2008 Apr;
138(5):954-63.
PMID: 18424607
Recent evidence has suggested that an imbalance between membrane (n-3) and (n-6) fatty acids may contribute to the etiology of autoimmune and neurodegenerative diseases. In this study, the mechanisms by...
3.
Boston P, Bennett A, Horrobin D, Bennett C
Prostaglandins Leukot Essent Fatty Acids
. 2004 Sep;
71(5):341-6.
PMID: 15380822
This pilot study of ethyl-eicosapentaenoate (ethyl-EPA) in the treatment of Alzheimer's disease aimed to estimate the magnitude of any change in measures of cognition during a 12-week treatment period. A...
4.
Lonergan P, Martin D, Horrobin D, Lynch M
J Neurochem
. 2004 Sep;
91(1):20-9.
PMID: 15379883
Eicosapentaenoic acid (EPA) protects hippocampus from age-related and irradiation-induced changes that lead to impairment in synaptic function; the evidence suggests that this is due to its anti-inflammatory effects, specifically preventing...
5.
Ayton A, Azaz A, Horrobin D
Prostaglandins Leukot Essent Fatty Acids
. 2004 Aug;
71(4):205-9.
PMID: 15301789
Anorexia nervosa (AN) carries the highest risk of morbidity and mortality amongst psychiatric disorders. The efficacy of current treatment approaches is limited. Despite the fat-phobic nature of the disease, poly-unsaturated...
6.
Ayton A, Azaz A, Horrobin D
Eur Psychiatry
. 2004 Jul;
19(5):317-9.
PMID: 15276668
No abstract available.
7.
Song C, Leonard B, Horrobin D
Stress
. 2004 Jun;
7(1):43-54.
PMID: 15204032
Omega (n)-3 and n-6 fatty acids are important membrane components of neurons and immune cells, and related to psychiatric and inflammatory diseases. Increased ratio of n-6/n-3 in the blood has...
8.
Murck H, Song C, Horrobin D, Uhr M
Int J Neuropsychopharmacol
. 2004 Mar;
7(3):341-9.
PMID: 15003146
Preliminary evidence shows that ethyl-eicosapentaenoate (E-EPA) has a marked clinical effect when used as an adjunct in therapy-refractory depression. EPA belongs to the class of polyunsaturated omega-3 fatty acids. The...
9.
10.
Macdonald D, Boyle R, Glen A, Horrobin D
Blood
. 2004 Jan;
103(9):3562-4.
PMID: 14726390
Phospholipase A(2) type IVA (IVAPLA(2)) is a cytosolic enzyme that on activation selectively releases arachidonic acid (AA) from cell membrane phospholipids. Both AA and lysophospholipid, products of the enzymic reaction,...