David E Symer
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Explore the profile of David E Symer including associated specialties, affiliations and a list of published articles.
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32
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1741
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Recent Articles
21.
Hertlein E, Beckwith K, Lozanski G, Chen T, Towns W, Johnson A, et al.
PLoS One
. 2013 Oct;
8(10):e76607.
PMID: 24130782
Studies of chronic lymphocytic leukemia (CLL) have yielded substantial progress, however a lack of immortalized cell lines representative of the primary disease has hampered a full understanding of disease pathogenesis...
22.
He H, Li W, Wu D, Nagy R, Liyanarachchi S, Akagi K, et al.
PLoS One
. 2013 May;
8(5):e61920.
PMID: 23690926
Thyroid cancer shows high heritability but causative genes remain largely unknown. According to a common hypothesis the genetic predisposition to thyroid cancer is highly heterogeneous; being in part due to...
23.
He H, Bronisz A, Liyanarachchi S, Nagy R, Li W, Huang Y, et al.
J Clin Endocrinol Metab
. 2013 Mar;
98(5):E973-80.
PMID: 23539728
Background: Papillary thyroid carcinoma (PTC) shows high heritability, yet efforts to find predisposing genes have been largely negative. Objectives: The objective of this study was to identify susceptibility genes for...
24.
Akagi K, Li J, Symer D
Bioessays
. 2013 Jan;
35(4):397-407.
PMID: 23319453
In this essay, we discuss new insights into the wide-ranging impacts of mammalian transposable elements (TE) on gene expression and function. Nearly half of each mammalian genome is comprised of...
25.
Prufer K, Munch K, Hellmann I, Akagi K, Miller J, Walenz B, et al.
Nature
. 2012 Jun;
486(7404):527-31.
PMID: 22722832
Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and chimpanzees differ...
26.
Li J, Akagi K, Hu Y, Trivett A, Hlynialuk C, Swing D, et al.
Genome Res
. 2012 Feb;
22(5):870-84.
PMID: 22367191
Endogenous retrotransposons have caused extensive genomic variation within mammalian species, but the functional implications of such mobilization are mostly unknown. We mapped thousands of endogenous retrovirus (ERV) germline integrants in...
27.
Billington Jr C, Ng B, Forsman C, Schmidt B, Bagchi A, Symer D, et al.
Dev Biol
. 2011 May;
355(1):21-31.
PMID: 21549111
The severity of numerous developmental abnormalities can vary widely despite shared genetic causes. Mice deficient in Twisted gastrulation (Twsg1(-/-)) display such phenotypic variation, developing a wide range of craniofacial malformations...
28.
He H, Liyanarachchi S, Akagi K, Nagy R, Li J, Dietrich R, et al.
Science
. 2011 Apr;
332(6026):238-40.
PMID: 21474760
Small nuclear RNAs (snRNAs) are essential factors in messenger RNA splicing. By means of homozygosity mapping and deep sequencing, we show that a gene encoding U4atac snRNA, a component of...
29.
Schneider A, Duffield A, Symer D, Burns K
Cellscience
. 2010 Mar;
6(2):121-145.
PMID: 20200603
Nearly half of our genomes are repetitive sequences derived from retrotransposons. These repeats have accumulated by a 'copy-and-paste' mechanism whereby: (i.) a genomic template sequence is transcribed to RNA, (ii.)...
30.
Akagi K, Stephens R, Li J, Evdokimov E, Kuehn M, Volfovsky N, et al.
Nucleic Acids Res
. 2009 Nov;
38(Database issue):D600-6.
PMID: 19933259
MouseIndelDB is an integrated database resource containing thousands of previously unreported mouse genomic indel (insertion and deletion) polymorphisms ranging from approximately 100 nt to 10 Kb in size. The database...