David E Simcock
Overview
Explore the profile of David E Simcock including associated specialties, affiliations and a list of published articles.
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12
Citations
351
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Recent Articles
1.
Jolliffe D, James W, Hooper R, Barnes N, Greiller C, Islam K, et al.
J Steroid Biochem Mol Biol
. 2017 Feb;
175:138-145.
PMID: 28161533
Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD), yet a comprehensive analysis of environmental and genetic determinants of serum 25-hydroxyvitamin D (25[OH]D) concentration in patients...
2.
Jolliffe D, Kilpin K, MacLaughlin B, Greiller C, Hooper R, Barnes N, et al.
J Steroid Biochem Mol Biol
. 2016 Nov;
175:88-96.
PMID: 27825992
Vitamin D deficiency is common in children with asthma, and it associates with poor asthma control, reduced forced expiratory volume in one second (FEV) and increased requirement for inhaled corticosteroids...
3.
Martineau A, MacLaughlin B, Hooper R, Barnes N, Jolliffe D, Greiller C, et al.
Thorax
. 2015 Mar;
70(5):451-7.
PMID: 25724847
Rationale: Asthma exacerbations are commonly precipitated by viral upper respiratory infections (URIs). Vitamin D insufficiency associates with susceptibility to URI in patients with asthma. Trials of vitamin D in adults...
4.
Martineau A, James W, Hooper R, Barnes N, Jolliffe D, Greiller C, et al.
Lancet Respir Med
. 2014 Dec;
3(2):120-130.
PMID: 25476069
Background: Patients with chronic obstructive pulmonary disease (COPD) often have vitamin D deficiency, which is associated with increased susceptibility to upper respiratory infection-a major precipitant of exacerbation. Multicentre trials of...
5.
Bredenoord A, Jafari J, Kadri S, Simcock D, Sifrim D, Preston S
Gut
. 2010 Nov;
60(2):153-5.
PMID: 21051451
We present a case of a patient with sarcoidosis and who subsequently developed dysphagia for solids, and some difficulty in swallowing liquids. High-resolution manometry of the oesophagus showed absent peristalsis...
6.
Pfeffer P, Sen A, Das S, Sheaff M, Sivaramakrishnan A, Simcock D, et al.
Thorax
. 2010 Oct;
65(12):1066, 1085.
PMID: 20889522
No abstract available.
7.
Bhalla R, Das S, Aleong J, Philpott D, Fry A, Simcock D
Br J Hosp Med (Lond)
. 2010 Jul;
71(7):410-1.
PMID: 20631660
No abstract available.
8.
Mahn K, Hirst S, Ying S, Holt M, Lavender P, Ojo O, et al.
Proc Natl Acad Sci U S A
. 2009 Jun;
106(26):10775-80.
PMID: 19541629
Phenotypic modulation of airway smooth muscle (ASM) is an important feature of airway remodeling in asthma that is characterized by enhanced proliferation and secretion of pro-inflammatory chemokines. These activities are...
9.
Bailey S, Boustany S, Burgess J, Hirst S, Sharma H, Simcock D, et al.
Pulm Pharmacol Ther
. 2009 May;
22(5):417-25.
PMID: 19409504
Altered bronchial vascular reactivity and remodelling including angiogenesis are documented features of asthma and other chronic inflammatory airway diseases. Expansion of the bronchial vasculature under these conditions involves both functional...
10.
Simcock D, Kanabar V, Clarke G, Mahn K, Karner C, OConnor B, et al.
Am J Respir Crit Care Med
. 2008 Jun;
178(5):460-8.
PMID: 18556625
Rationale: Airway remodeling in asthma involves accumulation of airway smooth muscle (ASM) and increased vascularity due to angiogenesis. Bronchial blood vessels and ASM are found in close proximity, and ASM...