David E Pleasure
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Explore the profile of David E Pleasure including associated specialties, affiliations and a list of published articles.
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29
Citations
877
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Recent Articles
1.
Wang M, Caryotakis S, Smith G, Nguyen A, Pleasure D, Soulika A
J Neuroinflammation
. 2024 Apr;
21(1):103.
PMID: 38643194
Background: Colony stimulating factor 1 receptor (CSF1R) signaling is crucial for the maintenance and function of various myeloid subsets. CSF1R antagonism was previously shown to mitigate clinical severity in experimental...
2.
Chen C, Jiang P, Xue H, Peterson S, Tran H, McCann A, et al.
Nat Commun
. 2020 Feb;
11(1):1070.
PMID: 32081845
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
3.
Yamagami T, Pleasure D, Lam K, Zhou C
Biochem Biophys Res Commun
. 2018 Feb;
496(4):1302-1307.
PMID: 29410176
After traumatic spinal cord injury (SCI), a scar may form with a fibrotic core (fibrotic scar) and surrounding reactive astrocytes (glial scar) at the lesion site. The scar tissue is...
4.
Jiang P, Chen C, Liu X, Pleasure D, Liu Y, Deng W
Cell Rep
. 2016 May;
15(6):1303-15.
PMID: 27134175
Astrocytes, once considered passive support cells, are increasingly appreciated as dynamic regulators of neuronal development and function, in part via secreted factors. The extent to which they similarly regulate oligodendrocytes...
5.
Liu X, Shen Y, Pleasure D, Deng W
BMC Neurosci
. 2016 Jan;
17:2.
PMID: 26733225
Background: Periventricular leukomalacia (PVL) is the leading cause of neurological disabilities including motor and cognitive deficits in premature infants. Periventricular leukomalacia is characterized by damage to the white matter in...
6.
Chen C, Jiang P, Xue H, Peterson S, Tran H, McCann A, et al.
Nat Commun
. 2014 Jul;
5:4430.
PMID: 25034944
Down's syndrome (DS), caused by trisomy of human chromosome 21, is the most common genetic cause of intellectual disability. Here we use induced pluripotent stem cells (iPSCs) derived from DS...
7.
Zhao T, Gan Q, Stokes A, Lassiter R, Wang Y, Chan J, et al.
Development
. 2013 Nov;
141(1):148-57.
PMID: 24284205
Non-canonical Wnt/planar cell polarity (PCP) signaling plays a primary role in the convergent extension that drives neural tube closure and body axis elongation. PCP signaling gene mutations cause severe neural...
8.
Jiang P, Chen C, Liu X, Selvaraj V, Liu W, Feldman D, et al.
Stem Cells
. 2013 Aug;
31(12):2620-31.
PMID: 23940003
Pluripotent stem cells (PSCs) have been differentiated into oligodendroglial progenitor cells (OPCs), providing promising cell replacement therapies for many central nervous system disorders. Studies from rodents have shown that brain...
9.
Jiang P, Chen C, Wang R, Chechneva O, Chung S, Rao M, et al.
Nat Commun
. 2013 Jul;
4:2196.
PMID: 23880652
Human pluripotent stem cells (hPSCs) have been differentiated to astroglia, but the utilization of hPSC-derived astroglia as cell therapy for neurological diseases has not been well studied. Astroglia are heterogeneous,...
10.
Daugherty D, Selvaraj V, Chechneva O, Liu X, Pleasure D, Deng W
EMBO Mol Med
. 2013 May;
5(6):891-903.
PMID: 23681668
Local production of neurosteroids such as progesterone and allopregnanolone confers neuroprotection in central nervous system (CNS) inflammatory diseases. The mitochondrial translocator protein (TSPO) performs a rate-limiting step in the conversion...