David D OKeefe
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Explore the profile of David D OKeefe including associated specialties, affiliations and a list of published articles.
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13
Citations
361
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Recent Articles
1.
Jhang J, Park S, Liu S, OKeefe D, Han S
Nat Neurosci
. 2024 Nov;
27(12):2455-2465.
PMID: 39562791
Although breathing is primarily automatic, its modulation by behavior and emotions suggests cortical inputs to brainstem respiratory networks, which hitherto have received little characterization. Here we identify in mice a...
2.
Jhang J, Liu S, OKeefe D, Han S
bioRxiv
. 2023 Mar;
PMID: 36909649
Breathing is profoundly influenced by both behavior and emotion and is the only physiological parameter that can be volitionally controlled. This indicates the presence of cortical-to-brainstem pathways that directly control...
3.
Hishida T, Vazquez-Ferrer E, Hishida-Nozaki Y, Takemoto Y, Hatanaka F, Yoshida K, et al.
Front Cell Dev Biol
. 2022 Mar;
10:786031.
PMID: 35309931
It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid....
4.
Shadel G, Adams P, Berggren W, Diedrich J, Diffenderfer K, Gage F, et al.
Geroscience
. 2021 Aug;
43(5):2139-2148.
PMID: 34370163
Understanding basic mechanisms of aging holds great promise for developing interventions that prevent or delay many age-related declines and diseases simultaneously to increase human healthspan. However, a major confounding factor...
5.
Kurita M, Araoka T, Hishida T, OKeefe D, Takahashi Y, Sakamoto A, et al.
Nature
. 2018 Sep;
561(7722):243-247.
PMID: 30185909
Large cutaneous ulcers are, in severe cases, life threatening. As the global population ages, non-healing ulcers are becoming increasingly common. Treatment currently requires the transplantation of pre-existing epithelial components, such...
6.
Liao H, Hatanaka F, Araoka T, Reddy P, Wu M, Sui Y, et al.
Cell
. 2017 Dec;
171(7):1495-1507.e15.
PMID: 29224783
Current genome-editing systems generally rely on inducing DNA double-strand breaks (DSBs). This may limit their utility in clinical therapies, as unwanted mutations caused by DSBs can have deleterious effects. CRISPR/Cas9...
7.
OKeefe D, Thomas S, Edgar B, Buttitta L
Dev Dyn
. 2014 Mar;
243(6):818-32.
PMID: 24591046
Background: The Decapentaplegic (Dpp) signaling pathway is used in many developmental and homeostatic contexts, each time resulting in cellular responses particular to that biological niche. The flexibility of Dpp signaling...
8.
OKeefe D, Thomas S, Bolin K, Griggs E, Edgar B, Buttitta L
BMC Genomics
. 2012 Sep;
13:498.
PMID: 22992320
Background: The transformation of a developing epithelium into an adult structure is a complex process, which often involves coordinated changes in cell proliferation, metabolism, adhesion, and shape. To identify genetic...
9.
OKeefe D, Gonzalez-Nino E, Edgar B, Curtiss J
Dev Biol
. 2012 Jul;
369(2):223-34.
PMID: 22776378
Mechanisms that govern cell-fate specification within developing epithelia have been intensely investigated, with many of the critical intercellular signaling pathways identified, and well characterized. Much less is known, however, about...
10.
OKeefe D, Edgar B, Saucedo L
Mech Dev
. 2010 Nov;
128(1-2):59-70.
PMID: 21055464
Signaling through the Notch receptor has dramatically different effects depending on cell type and developmental timing. While a myriad of biological systems affected by Notch have been described, the molecular...