David Clynes
Overview
Explore the profile of David Clynes including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
17
Citations
810
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0
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Recent Articles
11.
Howe F, Boubriak I, Sale M, Nair A, Clynes D, Grijzenhout A, et al.
Mol Cell
. 2014 Aug;
55(5):733-44.
PMID: 25127513
Gene transcription responds to stress and metabolic signals to optimize growth and survival. Histone H3 (H3) lysine 4 trimethylation (K4me3) facilitates state changes, but how levels are coordinated with the...
12.
Clynes D, Jelinska C, Xella B, Ayyub H, Taylor S, Mitson M, et al.
PLoS One
. 2014 Mar;
9(3):e92915.
PMID: 24651726
The chromatin remodeling protein ATRX, which targets tandem repetitive DNA, has been shown to be required for expression of the alpha globin genes, for proliferation of a variety of cellular...
13.
Clynes D, Higgs D, Gibbons R
Trends Biochem Sci
. 2013 Aug;
38(9):461-6.
PMID: 23916100
The regulation of chromatin structure is of paramount importance for a variety of fundamental nuclear processes, including gene expression, DNA repair, replication, and recombination. The ATP-dependent chromatin-remodelling factor ATRX (α...
14.
Clynes D, Gibbons R
Curr Opin Genet Dev
. 2013 Mar;
23(3):289-94.
PMID: 23453691
Understanding the underlying molecular basis for disease can often be a prolonged and tortuous process with many false leads and blind alleys. Relating the cause of ATR-X syndrome to the...
15.
Eustermann S, Yang J, Law M, Amos R, Chapman L, Jelinska C, et al.
Nat Struct Mol Biol
. 2011 Jun;
18(7):777-82.
PMID: 21666677
Accurate read-out of chromatin modifications is essential for eukaryotic life. Mutations in the gene encoding X-linked ATRX protein cause a mental-retardation syndrome, whereas wild-type ATRX protein targets pericentric and telomeric...
16.
Pinskaya M, Nair A, Clynes D, Morillon A, Mellor J
Mol Cell Biol
. 2009 Mar;
29(9):2419-30.
PMID: 19273607
The SANT domain is a nucleosome recognition module found in transcriptional regulatory proteins, including chromatin-modifying enzymes. It shows high functional degeneracy between species, varying in sequence and copy number. Here,...
17.
Mellor J, Dudek P, Clynes D
Curr Opin Genet Dev
. 2008 Feb;
18(2):116-22.
PMID: 18295475
Post-translational modifications to histone proteins and methylation of DNA comprise the epigenome of a cell. The epigenome, which changes through development, controls access to our genes. Recent advances in DNA...
18.
Walter W, Clynes D, Tang Y, Marmorstein R, Mellor J, Berger S
Mol Cell Biol
. 2008 Feb;
28(8):2840-9.
PMID: 18268010
Histone modifications occur in precise patterns and are proposed to signal the recruitment of effector molecules that profoundly impact chromatin structure, gene regulation, and cell cycle events. The linked modifications...
19.
MacDonald N, Welburn J, Noble M, Nguyen A, Yaffe M, Clynes D, et al.
Mol Cell
. 2005 Oct;
20(2):199-211.
PMID: 16246723
Phosphorylation of histone H3 is implicated in transcriptional activation and chromosome condensation, but its immediate molecular function has remained obscure. By affinity chromatography of nuclear extracts against modified H3 tail...