David Arribas-Layton
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Explore the profile of David Arribas-Layton including associated specialties, affiliations and a list of published articles.
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145
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Recent Articles
1.
Do J, Arribas-Layton D, Juan J, Garcia I, Saraswathy S, Qi M, et al.
J Autoimmun
. 2024 Apr;
146:103228.
PMID: 38642507
CD6 is a glycoprotein expressed on CD4 and CD8 T cells involved in immunoregulation. CD318 has been identified as a CD6 ligand. The role of CD318 in T cell immunity...
2.
Ettinger R, Buitinga M, Vandamme C, Afonso G, Gomez R, Arribas-Layton D, et al.
J Clin Endocrinol Metab
. 2023 Jul;
109(1):183-196.
PMID: 37474341
Context: Validated assays to measure autoantigen-specific T-cell frequency and phenotypes are needed for assessing the risk of developing diabetes, monitoring disease progression, evaluating responses to treatment, and personalizing antigen-based therapies....
3.
Nguyen H, Arribas-Layton D, Chow I, Speake C, Kwok W, Hessner M, et al.
Front Immunol
. 2023 Jan;
13:1015855.
PMID: 36703975
Introduction: Previous studies verify the formation of enzymatically post-translationally modified (PTM) self-peptides and their preferred recognition by T cells in subjects with type 1 diabetes (T1D). However, questions remain about...
4.
Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes
Guyer P, Arribas-Layton D, Manganaro A, Speake C, Lord S, Eizirik D, et al.
Diabetes
. 2022 Oct;
72(1):85-96.
PMID: 36201618
A recent discovery effort resulted in identification of novel splice variant and secretory granule antigens within the HLA class I peptidome of human islets and documentation of their recognition by...
5.
Song J, Schwenzer A, Wong A, Turcinov S, Rims C, Martinez L, et al.
JCI Insight
. 2021 Jan;
6(5).
PMID: 33507879
Tenascin-C (TNC), an extracellular matrix protein that has proinflammatory properties, is a recently described antibody target in rheumatoid arthritis (RA). In this study, we utilized a systematic discovery process and...
6.
Arribas-Layton D, Guyer P, Delong T, Dang M, Chow I, Speake C, et al.
Diabetes
. 2020 Apr;
69(7):1492-1502.
PMID: 32291282
T cells isolated from the pancreatic infiltrates of nonobese diabetic mice have been shown to recognize epitopes formed by the covalent cross-linking of proinsulin and secretory granule peptides. Formation of...
7.
Buitinga M, Callebaut A, Sodre F, Crevecoeur I, Blahnik-Fagan G, Yang M, et al.
Diabetes
. 2018 Oct;
67(11):2337-2348.
PMID: 30348823
The β-cell has become recognized as a central player in the pathogenesis of type 1 diabetes with the generation of neoantigens as potential triggers for breaking immune tolerance. We report...
8.
Scholz E, Marcilla M, Daura X, Arribas-Layton D, James E, Alvarez I
Front Immunol
. 2017 Sep;
8:984.
PMID: 28871256
Human leukocyte antigen (HLA)-DR15 is a haplotype associated with multiple sclerosis. It contains the two DRB* genes * (DR2b) and * (DR2a). The reported anchor motif of the corresponding HLA-DR...
9.
Acevedo-Calado M, James E, Morran M, Pietropaolo S, OuYang Q, Arribas-Layton D, et al.
Diabetes Care
. 2017 Feb;
40(4):561-568.
PMID: 28174261
Objective: The characterization of diverse subtypes of diabetes is a dynamic field of clinical research and an active area of discussion. The objective of this study was to identify new...
10.
Serrao E, Wang C, Frederick T, Lee C, Anthony P, Arribas-Layton D, et al.
J Med Virol
. 2014 Feb;
86(4):678-86.
PMID: 24482297
Multiple human proteins have been shown to both support and restrict viral replication, and confirmation of virus-associated changes in the expression of these genes is relevant for future therapeutic efforts....