David Alsina
Overview
Explore the profile of David Alsina including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
285
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0
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Recent Articles
1.
El Fissi N, Rosenberger F, Chang K, Wilhalm A, Barton-Owen T, Hansen F, et al.
Nat Commun
. 2024 Dec;
15(1):10719.
PMID: 39715749
Aberration of mitochondrial function is a shared feature of many human pathologies, characterised by changes in metabolic flux, cellular energetics, morphology, composition, and dynamics of the mitochondrial network. While some...
2.
Mennuni M, Wilkie S, Michon P, Alsina D, Filograna R, Lindberg M, et al.
Sci Adv
. 2024 Nov;
10(44):eadp3481.
PMID: 39485842
Lung adenocarcinoma is a common aggressive cancer and a leading cause of mortality worldwide. Here, we report an important in vivo role for mitochondrial DNA (mtDNA) copy number during lung...
3.
Jiang S, Yuan T, Rosenberger F, Mourier A, Dragano N, Kremer L, et al.
Nat Metab
. 2024 Apr;
6(6):1024-1035.
PMID: 38689023
The oxidative phosphorylation system in mammalian mitochondria plays a key role in transducing energy from ingested nutrients. Mitochondrial metabolism is dynamic and can be reprogrammed to support both catabolic and...
4.
Filograna R, Mennuni M, Alsina D, Larsson N
FEBS Lett
. 2020 Dec;
595(8):976-1002.
PMID: 33314045
Most of the genetic information has been lost or transferred to the nucleus during the evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that is essential for oxidative...
5.
Alsina D, Lytovchenko O, Schab A, Atanassov I, Schober F, Jiang M, et al.
EMBO Mol Med
. 2020 Jun;
12(7):e11659.
PMID: 32525278
Pathogenic variants in FBXL4 cause a severe encephalopathic syndrome associated with mtDNA depletion and deficient oxidative phosphorylation. To gain further insight into the enigmatic pathophysiology caused by FBXL4 deficiency, we...
6.
Alsina D, Purroy R, Ros J, Tamarit J
Pharmaceuticals (Basel)
. 2018 Sep;
11(3).
PMID: 30235822
Friedreich ataxia is a neurodegenerative disease with an autosomal recessive inheritance. In most patients, the disease is caused by the presence of trinucleotide GAA expansions in the first intron of...
7.
Alsina D, Ros J, Tamarit J
Redox Biol
. 2017 Sep;
14:131-141.
PMID: 28918000
Yeast frataxin homolog (Yfh1) is the orthologue of human frataxin, a mitochondrial protein whose deficiency causes Friedreich Ataxia. Yfh1 deficiency activates Aft1, a transcription factor governing iron homeostasis in yeast...
8.
Moreno-Cermeno A, Alsina D, Cabiscol E, Tamarit J, Ros J
Biochim Biophys Acta
. 2013 Oct;
1833(12):3326-3337.
PMID: 24100161
Frataxin is a mitochondrial protein involved in iron metabolism whose deficiency in humans causes Friedreich ataxia. We performed transcriptomic and proteomic analyses of conditional Yeast Frataxin Homologue (Yfh1) mutants (tetO7-YFH1)...
9.
Tamarit J, de Hoogh A, Obis E, Alsina D, Cabiscol E, Ros J
J Proteomics
. 2012 May;
75(12):3778-88.
PMID: 22579746
Protein carbonyl detection has been commonly used to analyze the degree of damage to proteins under oxidative stress conditions. Most laboratories rely on derivatization of carbonyl groups with dinitrophenylhydrazine followed...