David A Middleton
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Explore the profile of David A Middleton including associated specialties, affiliations and a list of published articles.
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68
Citations
523
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Recent Articles
1.
Middleton D
Prog Nucl Magn Reson Spectrosc
. 2024 Dec;
144-145:63-96.
PMID: 39645351
Amyloid fibrils are insoluble, fibrous nanostructures that accumulate extracellularly in biological tissue during the progression of several human disorders, including Alzheimer's disease (AD) and type 2 diabetes. Fibrils are assembled...
2.
Alaziqi B, Beckitt L, Townsend D, Morgan J, Price R, Maerivoet A, et al.
ACS Omega
. 2024 Aug;
9(30):32557-32578.
PMID: 39100310
The dietary consumption of extra virgin olive oil (EVOO) is believed to slow the progression of Alzheimer's disease (AD) symptoms. Its protective mechanisms are unclear, but specific EVOO phenolic compounds...
3.
Middleton D, Griffin J, Esmann M, Fedosova N
RSC Adv
. 2023 Nov;
13(49):34836-34846.
PMID: 38035247
Structures of membrane proteins determined by X-ray crystallography and, increasingly, by cryo-electron microscopy often fail to resolve the structural details of unstable or reactive small molecular ligands in their physiological...
4.
Lau S, Middleton D
Phys Chem Chem Phys
. 2022 Sep;
24(38):23651-23660.
PMID: 36134896
Cholesterol is an essential component of eukaryotic cellular membranes that regulates the order and phase behaviour of dynamic lipid bilayers. Although cholesterol performs many vital physiological roles, hypercholesterolaemia and the...
5.
Mapley B, Townsend D, Griffin J, Ashton L, Middleton D
Chempluschem
. 2021 Nov;
86(11):1517-1523.
PMID: 34726840
Drug interactions with phospholipid bilayers underpin their behaviour in cell membranes and in liposomal delivery formulations. Liposomal drug delivery in ocular medicine can overcome the physical barriers of the eye...
6.
Townsend D, Fullwood N, Yates E, Middleton D
Biochemistry
. 2020 Sep;
59(41):4003-4014.
PMID: 32954725
A pathological signature of Alzheimer's disease (AD) is the formation of neurofibrillary tangles comprising filamentous aggregates of the microtubule associated protein tau. Tau self-assembly is accelerated by polyanions including heparin,...
7.
Townsend D, Middleton D, Ashton L
Anal Chem
. 2020 Sep;
92(20):13822-13828.
PMID: 32935978
It has been shown extensively that glycosaminoglycan (GAG)-protein interactions can induce, accelerate, and impede the clearance of amyloid fibrils associated with systemic and localized amyloidosis. Obtaining molecular details of these...
8.
Lau S, Middleton D
Angew Chem Int Ed Engl
. 2020 Jun;
59(41):18126-18130.
PMID: 32542937
The biological function of high-density lipoprotein (HDL) nanoparticles, the so-called good cholesterol that is associated with a low risk of heart disease, depends on their composition, morphology, and size. The...
9.
Townsend D, Mala B, Hughes E, Hussain R, Siligardi G, Fullwood N, et al.
ACS Chem Neurosci
. 2020 Jun;
11(14):2104-2116.
PMID: 32520518
Potential drug treatments for Alzheimer's disease (AD) may be found by identifying compounds that block the assembly of the microtubule-associated protein tau into neurofibrillar tangles associated with neuron destabilization and...
10.
Lau S, Stanhope N, Griffin J, Hughes E, Middleton D
Chem Commun (Camb)
. 2019 Oct;
55(88):13287-13290.
PMID: 31626247
NMR measurements of 19F chemical shift anisotropy and 1H-19F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density...