David A MacIntyre
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Explore the profile of David A MacIntyre including associated specialties, affiliations and a list of published articles.
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79
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2621
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Recent Articles
1.
Decout A, Krasias I, Roberts L, Gimeno Molina B, Charenton C, Brown Romero D, et al.
Nat Commun
. 2024 Dec;
15(1):10879.
PMID: 39737998
Lactobacillus species dominance of the vaginal microbiome is a hallmark of vaginal health. Pathogen displacement of vaginal lactobacilli drives innate immune activation and mucosal barrier disruption, increasing the risks of...
2.
Corbett G, Corcoran S, Feehily C, Soldati B, Rafferty A, MacIntyre D, et al.
Contemp Clin Trials
. 2024 Dec;
149:107776.
PMID: 39701375
Introduction: Effective spontaneous preterm birth (sPTB) prevention is an urgent unmet clinical need. Vaginal depletion of Lactobacillus crispatus is linked to sPTB. This trial will investigate impact of an oral...
3.
Kundu S, Dos Santos Correia G, Lee Y, Ng S, Sykes L, Chan D, et al.
Microb Genom
. 2024 Dec;
10(12).
PMID: 39630497
Mutations in the gene that result in a lack of expression of histo-blood group antigens on secreted glycoproteins may shape the vaginal microbiota with consequences for birth outcome. To test...
4.
Corbett G, Moore R, Feehily C, Killeen S, OBrien E, Van Sinderen D, et al.
Microbiol Spectr
. 2024 Oct;
12(11):e0113024.
PMID: 39365058
Importance: This secondary analysis of the MicrobeMom randomized controlled trial reveals that dietary amino acids, macronutrients, previous vaginal birth, and breastfeeding have the strongest associations with vaginal taxonomy in early...
5.
Parraga-Leo A, Oskotsky T, Oskotsky B, Wibrand C, Roldan A, Tang A, et al.
JAMIA Open
. 2024 Sep;
7(3):ooae099.
PMID: 39345789
Objectives: To enable interactive visualization of the vaginal microbiome across the pregnancy and facilitate discovery of novel insights and generation of new hypotheses. Material And Methods: Vaginal Microbiome Atlas during...
6.
Wu G, Grassi P, Gimeno Molina B, MacIntyre D, Sykes L, Bennett P, et al.
Sci Rep
. 2024 Sep;
14(1):20813.
PMID: 39242814
During pregnancy the immune system needs to maintain immune tolerance of the foetus while also responding to infection, which can cause premature activation of the inflammatory pathways leading to the...
7.
Semertzidou A, Whelan E, Smith A, Ng S, Roberts L, Brosens J, et al.
Microbiome
. 2024 Jul;
12(1):118.
PMID: 38951935
Background: Endometrial cancer is a multifactorial disease with inflammatory, metabolic and potentially microbial cues involved in disease pathogenesis. The endometrial cancer microbiome has been poorly characterised so far and studies...
8.
Odendaal J, Black N, Bennett P, Brosens J, Quenby S, MacIntyre D
Hum Reprod
. 2024 Jan;
39(4):638-646.
PMID: 38195891
The human endometrium is a dynamic entity that plays a pivotal role in mediating the complex interplay between the mother and developing embryo. Endometrial disruption can lead to pregnancy loss,...
9.
Golob J, Oskotsky T, Tang A, Roldan A, Chung V, Ha C, et al.
Cell Rep Med
. 2023 Dec;
5(1):101350.
PMID: 38134931
Every year, 11% of infants are born preterm with significant health consequences, with the vaginal microbiome a risk factor for preterm birth. We crowdsource models to predict (1) preterm birth...
10.
Huang C, Gin C, Fettweis J, Foxman B, Gelaye B, MacIntyre D, et al.
BMC Biol
. 2023 Sep;
21(1):199.
PMID: 37743497
Background: High-throughput sequencing measurements of the vaginal microbiome have yielded intriguing potential relationships between the vaginal microbiome and preterm birth (PTB; live birth prior to 37 weeks of gestation). However,...