David A Gillespie
Overview
Explore the profile of David A Gillespie including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
1935
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Recent Articles
1.
Hernandez-Suarez B, Gillespie D, Obminska-Mrukowicz B, Pawlak A
J Vet Res
. 2023 Oct;
67(3):447-458.
PMID: 37818142
Introduction: New and more effective therapies for canine cancer patients are urgently required and this necessitates advanced experimental research. Dogs are good models for studies in comparative oncology; however, canine...
2.
Hernandez-Suarez B, Gillespie D, Dejnaka E, Kupczyk P, Obminska-Mrukowicz B, Pawlak A
Front Vet Sci
. 2023 Sep;
10:1227683.
PMID: 37655260
Background: Dogs present a significant opportunity for studies in comparative oncology. However, the study of cancer biology phenomena in canine cells is currently limited by restricted availability of validated antibody...
3.
Gillespie D
FEBS J
. 2022 Mar;
290(7):1719-1724.
PMID: 35231158
Heritable loss-of-function mutations in genes encoding key regulators of DNA repair and genome stability can result in degenerative progeroid and/or cancer predisposition syndromes; however, such mutations have never been found...
4.
Hernandez-Suarez B, Gillespie D, Pawlak A
Vet Comp Oncol
. 2021 Dec;
20(2):347-361.
PMID: 34923737
The DNA damage response (DDR) is a complex signal transduction network that is activated when endogenous or exogenous genotoxins damage or interfere with the replication of genomic DNA. Under such...
5.
Smits V, Hernandez-Carralero E, Paz-Cabrera M, Cabrera E, Hernandez-Reyes Y, Hernandez-Fernaud J, et al.
Biochem Biophys Res Commun
. 2021 Jan;
543:45-49.
PMID: 33515911
In order to control the COVID-19 pandemic caused by SARS-CoV-2 infection, serious progress has been made to identify infected patients and to detect patients with a positive immune response against...
6.
Gong E, Hernandez B, Nielsen J, Smits V, Freire R, Gillespie D
Sci Rep
. 2018 Dec;
8(1):17536.
PMID: 30510197
The DNA damage-activated protein kinase Chk1 is known to undergo auto-phosphorylation, however the sites and functional significance of this modification remain poorly understood. We have identified two novel Chk1 auto-phosphorylation...
7.
Smits V, Cabrera E, Freire R, Gillespie D
FEBS J
. 2018 Jun;
286(3):441-455.
PMID: 29931808
Claspin was discovered as a Chk1-interacting protein necessary for Chk1 phosphorylation and activation by the upstream kinase, ATR, in response to DNA synthesis inhibition in Xenopus oocyte extracts. Subsequent investigations...
8.
Gillespie D, Ryan K
Mol Cell Oncol
. 2016 Jun;
3(1):e1030538.
PMID: 27308547
Autophagy delivers damaged cytoplasmic constituents to lysosomes for degradation, thus preserving cellular integrity and protecting against disease. Remarkably, autophagy-deficient cells also exhibit aberrant DNA damage responses with therapeutic implications, such...
9.
Smits V, Gillespie D
FEBS J
. 2015 Jul;
282(19):3681-92.
PMID: 26216057
Checkpoint kinase 1 (Chk1) is a master regulator of the DNA damage and replication checkpoints in vertebrate cells. When activated via phosphorylation by its upstream regulatory kinase, ATR, Chk1 prevents...
10.
Gong E, Smits V, Fumagallo F, Piscitello D, Morrice N, Freire R, et al.
Sci Rep
. 2015 Jun;
5:10856.
PMID: 26039276
The Chk1 protein kinase is activated in response to DNA damage through ATR-mediated phosphorylation at multiple serine-glutamine (SQ) residues within the C-terminal regulatory domain, however the molecular mechanism is not...