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David A DiGregorio

Explore the profile of David A DiGregorio including associated specialties, affiliations and a list of published articles. Areas
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Articles 28
Citations 1512
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Recent Articles
1.
Caze R, Tran-Van-Minh A, Gutkin B, DiGregorio D
Sci Rep . 2024 Aug; 14(1):18226. PMID: 39107382
Theory predicts that nonlinear summation of synaptic potentials within dendrites allows neurons to perform linearly non-separable computations (LNSCs). Using Boolean analysis approaches, we predicted that both supralinear and sublinear synaptic...
2.
Biane C, Ruckerl F, Abrahamsson T, Saint-Cloment C, Mariani J, Shigemoto R, et al.
Elife . 2021 Nov; 10. PMID: 34730085
Synaptic transmission, connectivity, and dendritic morphology mature in parallel during brain development and are often disrupted in neurodevelopmental disorders. Yet how these changes influence the neuronal computations necessary for normal...
3.
Rebola N, Reva M, Kirizs T, Szoboszlay M, Lorincz A, Moneron G, et al.
Neuron . 2021 Oct; 109(19):3178. PMID: 34619089
No abstract available.
4.
Reva M, DiGregorio D, Grebenkov D
Sci Rep . 2021 Mar; 11(1):5377. PMID: 33686123
Synaptic transmission between neurons is governed by a cascade of stochastic calcium ion reaction-diffusion events within nerve terminals leading to vesicular release of neurotransmitter. Since experimental measurements of such systems...
5.
Hoehne A, McFadden M, DiGregorio D
Elife . 2020 Sep; 9. PMID: 32990593
In the cerebellar cortex, molecular layer interneurons use chemical and electrical synapses to form subnetworks that fine-tune the spiking output of the cerebellum. Although electrical synapses can entrain activity within...
6.
Rebola N, Reva M, Kirizs T, Szoboszlay M, Lorincz A, Moneron G, et al.
Neuron . 2019 Sep; 104(4):693-710.e9. PMID: 31558350
The nanoscale topographical arrangement of voltage-gated calcium channels (VGCC) and synaptic vesicles (SVs) determines synaptic strength and plasticity, but whether distinct spatial distributions underpin diversity of synaptic function is unknown....
7.
Marvin J, Scholl B, Wilson D, Podgorski K, Kazemipour A, Muller J, et al.
Nat Methods . 2019 Mar; 16(4):351. PMID: 30820033
The version of this paper originally published cited a preprint version of ref. 12 instead of the published version (Proc. Natl. Acad. Sci. USA 115, 5594-5599; 2018), which was available...
8.
Fekete A, Nakamura Y, Yang Y, Herlitze S, Mark M, DiGregorio D, et al.
Nat Commun . 2019 Feb; 10(1):826. PMID: 30778063
Synaptic heterogeneity is widely observed but its underpinnings remain elusive. We addressed this issue using mature calyx of Held synapses whose numbers of bouton-like swellings on stalks of the nerve...
9.
Marvin J, Scholl B, Wilson D, Podgorski K, Kazemipour A, Muller J, et al.
Nat Methods . 2019 Jan; 16(2):206. PMID: 30602783
In the version of this paper originally published, important figure labels in Fig. 3d were not visible. An image layer present in the authors' original figure that included two small...
10.
Marvin J, Scholl B, Wilson D, Podgorski K, Kazemipour A, Muller J, et al.
Nat Methods . 2018 Nov; 15(11):936-939. PMID: 30377363
Single-wavelength fluorescent reporters allow visualization of specific neurotransmitters with high spatial and temporal resolution. We report variants of intensity-based glutamate-sensing fluorescent reporter (iGluSnFR) that are functionally brighter; detect submicromolar to...