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Darrell Henze

Explore the profile of Darrell Henze including associated specialties, affiliations and a list of published articles. Areas
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Articles 5
Citations 246
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Recent Articles
1.
Ballard J, Pall P, Vardigan J, Zhao F, Holahan M, Kraus R, et al.
Pharm Res . 2020 Sep; 37(10):181. PMID: 32888082
Purpose: This work describes a staged approach to the application of pharmacokinetic-pharmacodynamic (PK-PD) modeling in the voltage-gated sodium ion channel (NaV1.7) inhibitor drug discovery effort to address strategic questions regarding...
2.
Grauer S, Sanoja R, Poulin D, Rashid H, Jochnowitz N, Calhoun M, et al.
Brain Res . 2020 Apr; 1737:146814. PMID: 32234514
Analgesic properties of orthosteric agonists of the muscarinic M receptor subtype have been documented in literature reports, with evidence from pharmacological and in vivo receptor knock out (KO) studies. Constitutive...
3.
Solly K, Klein R, Rudd M, Holloway M, Johnson E, Henze D, et al.
J Biomol Screen . 2015 Feb; 20(6):708-19. PMID: 25700884
GluK1, a kainate subtype of ionotropic glutamate receptors, exhibits an expression pattern in the CNS consistent with involvement in pain processing and migraine. Antagonists of GluK1 have been shown to...
4.
Jinno S, Klausberger T, Marton L, Dalezios Y, Roberts J, Fuentealba P, et al.
J Neurosci . 2007 Aug; 27(33):8790-804. PMID: 17699661
The formation and recall of sensory, motor, and cognitive representations require coordinated fast communication among multiple cortical areas. Interareal projections are mainly mediated by glutamatergic pyramidal cell projections; only few...
5.
Buzsaki G, Csicsvari J, Dragoi G, Harris K, Henze D, Hirase H
Cereb Cortex . 2002 Aug; 12(9):893-9. PMID: 12183388
Information in neuronal networks is thought to be represented by the rate of discharge and the temporal relationship between the discharging neurons. The discharge frequency of neurons is affected by...