Dario Domenico Lofrumento
Overview
Explore the profile of Dario Domenico Lofrumento including associated specialties, affiliations and a list of published articles.
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Articles
49
Citations
796
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Recent Articles
1.
Ruggiero M, Cianciulli A, Calvello R, Lofrumento D, Saponaro C, Filannino F, et al.
Int J Mol Sci
. 2025 Jan;
26(1.
PMID: 39796258
Neurodegenerative diseases are characterized by progressive loss of neurons and persistent inflammation. Neurons are terminally differentiated cells, and lost neurons cannot be replaced since neurogenesis is restricted to only two...
2.
Filannino F, Ruggiero M, Panaro M, Lofrumento D, Trotta T, Benameur T, et al.
Molecules
. 2024 Dec;
29(23).
PMID: 39683782
Neuroinflammation is defined as an immune response involving various cell types, particularly microglia, which monitor the neuroimmune axis. Microglia activate in two distinct ways: M1, which is pro-inflammatory and capable...
3.
Miraglia A, Giannotti L, De Nuccio F, Treglia A, Maffia M, Lofrumento D, et al.
Histochem Cell Biol
. 2024 Nov;
163(1):6.
PMID: 39557701
Anaplastic thyroid carcinoma (ATC) ranks among the most lethal human cancers. Increased migratory and invasive capabilities are critical in malignancy and are often secondary to epithelial-mesenchymal transition (EMT). However, it...
4.
Ruggiero M, Cianciulli A, Calvello R, Porro C, De Nuccio F, Kashyrina M, et al.
Nutrients
. 2024 Apr;
16(8).
PMID: 38674812
Background: The prolonged activation of microglia and excessive production of pro-inflammatory cytokines can lead to chronic neuroinflammation, which is an important pathological feature of Parkinson's disease (PD). We have previously...
5.
Cianciulli A, Calvello R, Porro C, Lofrumento D, Panaro M
Cells
. 2024 Mar;
13(6.
PMID: 38534350
Inflammatory skin diseases include a series of disorders characterized by a strong activation of the innate and adaptive immune system in which proinflammatory cytokines play a fundamental role in supporting...
6.
Lofrumento D, Miraglia A, La Pesa V, Treglia A, Chieppa M, De Nuccio F, et al.
Endocrine
. 2023 Jun;
81(3):492-502.
PMID: 37306934
Purpose: In type 2 Diabetes, β-cell failure is caused by loss of cell mass, mostly by apoptosis, but also by simple dysfunction (dedifferentiation, decline of glucose-stimulated insulin secretion). Apoptosis and...
7.
Calvello R, Porro C, Lofrumento D, Ruggiero M, Panaro M, Cianciulli A
Cells
. 2023 Mar;
12(5).
PMID: 36899817
Resveratrol is a polyphenol that acts as antioxidants do, protecting the body against diseases, such as diabetes, cancer, heart disease, and neurodegenerative disorders, such as Alzheimer's (AD) and Parkinson's diseases...
8.
De Nuccio F, Kashyrina M, Serinelli F, Laferriere F, Lofrumento D, De Giorgi F, et al.
Biomolecules
. 2023 Feb;
13(2).
PMID: 36830639
α-Synucleinopathies are spreading neurodegenerative disorders characterized by the intracellular accumulation of insoluble aggregates populated by α-Synuclein (α-Syn) fibrils. In Parkinson's disease (PD) and dementia with Lewy bodies, intraneuronal α-Syn aggregates...
9.
La Torre M, Panaro M, Ruggiero M, Polito R, Cianciulli A, Filannino F, et al.
Biology (Basel)
. 2022 Oct;
11(10).
PMID: 36290330
Extracellular vesicles (EVs) represent a heterogeneous group of membranous structures derived from cells that are released by all cell types, including brain cells. EVs are now thought to be an...
10.
Spagnolo B, Balena A, Peixoto R, Pisanello M, Sileo L, Bianco M, et al.
Nat Mater
. 2022 Jun;
21(7):826-835.
PMID: 35668147
Deciphering the neural patterns underlying brain functions is essential to understanding how neurons are organized into networks. This deciphering has been greatly facilitated by optogenetics and its combination with optoelectronic...