Danita M Pearson
Overview
Explore the profile of Danita M Pearson including associated specialties, affiliations and a list of published articles.
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14
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1545
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Recent Articles
1.
Lambert S, Witt H, Hovestadt V, Zucknick M, Kool M, Pearson D, et al.
Acta Neuropathol
. 2013 May;
126(2):291-301.
PMID: 23660940
Pilocytic astrocytomas (PAs) are the most common brain tumors in pediatric patients and can cause significant morbidity, including chronic neurological deficiencies. They are characterized by activating alterations in the mitogen-activated...
2.
Mulholland S, Pearson D, Hamoudi R, Malley D, Smith C, Weaver J, et al.
Int J Cancer
. 2011 Oct;
131(5):1104-13.
PMID: 22020830
We have previously identified a region containing 16 CpGs within the MGMT CpG islands which is critical for the transcriptional control of MGMT (Malley, Acta Neuropathol 2011). To investigate the...
3.
Jones D, Mulholland S, Pearson D, Malley D, Openshaw S, Lambert S, et al.
Acta Neuropathol
. 2011 Feb;
121(6):753-61.
PMID: 21327941
Diffuse astrocytomas (WHO grade II) typically present as slow-growing tumours showing significant cellular differentiation, but possessing a tendency towards malignant progression. They account for ~10% of all astrocytic tumours, with...
4.
Malley D, Hamoudi R, Kocialkowski S, Pearson D, Collins V, Ichimura K
Acta Neuropathol
. 2011 Feb;
121(5):651-61.
PMID: 21287394
O(6)-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that removes alkyl DNA adducts such as those induced by alkylating agents. Loss of MGMT expression through transcriptional silencing by hypermethylation of...
5.
Vogazianou A, Chan R, Backlund L, Pearson D, Liu L, Langford C, et al.
Neuro Oncol
. 2010 Feb;
12(7):664-78.
PMID: 20164239
We studied the status of chromosomes 1 and 19 in 363 astrocytic and oligodendroglial tumors. Whereas the predominant pattern of copy number abnormality was a concurrent loss of the entire...
6.
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas
Ichimura K, Pearson D, Kocialkowski S, Backlund L, Chan R, Jones D, et al.
Neuro Oncol
. 2009 May;
11(4):341-7.
PMID: 19435942
We screened exon 4 of the gene isocitrate dehydrogenase 1 (NADP+), soluble (IDH1) for mutations in 596 primary intracranial tumors of all major types. Codon 132 mutation was seen in...
7.
Jones D, Kocialkowski S, Liu L, Pearson D, Backlund L, Ichimura K, et al.
Cancer Res
. 2008 Nov;
68(21):8673-7.
PMID: 18974108
Brain tumors are the most common solid tumors of childhood, and pilocytic astrocytomas (PA) are the most common central nervous system tumor in 5 to 19 year olds. Little is...
8.
McCabe M, Ichimura K, Pearson D, Liu L, Clifford S, Ellison D, et al.
Genes Chromosomes Cancer
. 2008 Nov;
48(2):121-31.
PMID: 18973140
Isodicentric 17q is the most commonly reported chromosomal abnormality in medulloblastomas. Its frequency suggests that genes disrupted in medulloblastoma formation may play a role in tumorigenesis. We have previously identified...
9.
Kurian K, Jones D, Marsden F, Openshaw S, Pearson D, Ichimura K, et al.
Brain Pathol
. 2008 Apr;
18(4):469-73.
PMID: 18397339
Subependymomas (SE) are slow-growing brain tumors that tend to occur within the ventricles of middle-aged and elderly adults. The World Health Organization classifies these tumors within the ependymoma group. Previous...
10.
Jones D, Ichimura K, Liu L, Pearson D, Plant K, Collins V
J Neuropathol Exp Neurol
. 2006 Nov;
65(11):1049-58.
PMID: 17086101
Brain tumors are the most common solid tumors of childhood, accounting for over 20% of cancers in children under 15 years of age. Pilocytic astrocytomas (PAs), World Health Organization grade...