Danielle Karakas
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Explore the profile of Danielle Karakas including associated specialties, affiliations and a list of published articles.
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8
Citations
30
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Recent Articles
1.
Mukkala A, David B, Ailenberg M, Liang J, Vaswani C, Karakas D, et al.
Ann Surg
. 2025 Feb;
PMID: 39912224
Objective: To investigate the hepatoprotective effects of mitochondrial transplantation in a murine liver ischemia/reperfusion (I/R) model. Summary Background Data: Sequential liver ischemia followed by reperfusion (I/R) is a pathophysiological process...
2.
Shen C, Mackeigan D, Shoara A, Bhoria P, Zhu G, Karakas D, et al.
J Thromb Haemost
. 2024 Aug;
22(11):3249-3265.
PMID: 39147240
Background: Snake venom botrocetin facilitates von Willebrand factor (VWF) binding to platelet GPIbα and has been widely used for the diagnosis of von Willebrand disease and GPIb-related disorders. Botrocetin is...
3.
4.
Li J, Karakas D, Xue F, Chen Y, Zhu G, Yucel Y, et al.
Research (Wash D C)
. 2023 Oct;
6:0236.
PMID: 37808178
Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of platelets...
5.
Ma X, Liang J, Zhu G, Bhoria P, Shoara A, Mackeigan D, et al.
Research (Wash D C)
. 2023 May;
6:0124.
PMID: 37223472
The COVID-19 pandemic caused by SARS-CoV-2 virus is an ongoing global health burden. Severe cases of COVID-19 and the rare cases of COVID-19 vaccine-induced-thrombotic-thrombocytopenia (VITT) are both associated with thrombosis...
6.
Shen C, Mackeigan D, Shoara A, Xu R, Bhoria P, Karakas D, et al.
J Thromb Haemost
. 2023 Feb;
21(5):1274-1288.
PMID: 36732162
Background: Platelet GPIbα-von Willebrand factor (VWF) interaction initiates platelet adhesion, activation, and thrombus growth, especially under high shear conditions. Therefore, the GPIb-VWF axis has been suggested as a promising target...
7.
Li F, Xiong Y, Yang M, Chen P, Zhang J, Wang Q, et al.
Cell Death Dis
. 2022 Oct;
13(10):869.
PMID: 36229456
Acute megakaryocytic leukemia (AMKL) is a clinically heterogeneous subtype of acute myeloid leukemia characterized by unrestricted megakaryoblast proliferation and poor prognosis. Thrombopoietin receptor c-Mpl is a primary regulator of megakaryopoeisis...
8.
Shen C, Liu M, MacKeigan D, Chen Z, Chen P, Karakas D, et al.
Arch Toxicol
. 2021 Sep;
95(11):3589-3599.
PMID: 34519865
Venomous snakebites cause clinical manifestations that range from local to systemic and are considered a significant global health challenge. Persistent or refractory thrombocytopenia has been frequently reported in snakebite patients,...
9.
Karakas D, Xu M, Ni H
Res Pract Thromb Haemost
. 2021 May;
5(4):e12506.
PMID: 33977209
Thrombopoietin (TPO), a glycoprotein hormone produced predominantly in the liver, plays important roles in the hematopoietic stem cell (HSC) niche, and is essential for megakaryopoiesis and platelet generation. Long-standing understanding...