Danielle E Skinner
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Explore the profile of Danielle E Skinner including associated specialties, affiliations and a list of published articles.
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12
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109
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Recent Articles
1.
Jiang Z, Silva E, Liu C, Fajtova P, Liu L, El-Sakkary N, et al.
bioRxiv
. 2024 Feb;
PMID: 38405969
Schistosomiasis, or bilharzia, is a neglected tropical disease caused by spp. blood flukes that infects over 200 million people worldwide. Just one partially effective drug is available, and new drugs...
2.
Yeh Y, Skinner D, Criado-Hidalgo E, Chen N, Garcia-De Herreros A, El-Sakkary N, et al.
PLoS Pathog
. 2022 Mar;
18(3):e1010309.
PMID: 35316298
The eggs of the parasitic blood fluke, Schistosoma, are the main drivers of the chronic pathologies associated with schistosomiasis, a disease of poverty afflicting approximately 220 million people worldwide. Eggs...
3.
Zorn K, Sun S, McConnon C, Ma K, Chen E, Foil D, et al.
ACS Infect Dis
. 2021 Jan;
7(2):406-420.
PMID: 33434015
Schistosomiasis is a chronic and painful disease of poverty caused by the flatworm parasite . Drug discovery for antischistosomal compounds predominantly employs whole organism (phenotypic) screens against two developmental stages...
4.
Monti L, Cornec A, Oukoloff K, Kovalevich J, Prijs K, Alle T, et al.
ACS Infect Dis
. 2020 Nov;
7(5):1089-1103.
PMID: 33135408
Schistosomiasis is a parasitic disease that affects approximately 200 million people in developing countries. Current treatment relies on just one partially effective drug, and new drugs are needed. Tubulin and...
5.
Probst A, Haberli C, Siegel D, Huang J, Vigneron S, Ta A, et al.
J Antimicrob Chemother
. 2020 Jul;
75(10):2925-2932.
PMID: 32617557
Background: Treatment of schistosomiasis, a neglected disease, relies on just one partially effective drug, praziquantel. We revisited the 9-acridanone hydrazone, Ro 15-5458, a largely forgotten antischistosomal lead compound. Methods: Ro...
6.
Singh S, El-Sakkary N, Skinner D, Sharma P, Ottilie S, Antonova-Koch Y, et al.
Pharmaceuticals (Basel)
. 2020 Feb;
13(2).
PMID: 32028743
The neglected tropical disease, schistosomiasis, is caused by trematode blood flukes of the genus and infects approximately 200 million people worldwide. With just one partially effective drug available for disease...
7.
Skinner D, Popratiloff A, Alrefaei Y, Mann V, Rinaldi G, Brindley P
Mol Biochem Parasitol
. 2020 Jan;
236:111259.
PMID: 31958469
The RNA helicase Vasa plays a pivotal role in the development of the germ line. To decipher the functional roles of vasa/PL10-like genes in the human blood fluke Schistosoma mansoni,...
8.
Yan H, Smout M, Ju C, Folley A, Skinner D, Mann V, et al.
Antimicrob Agents Chemother
. 2018 May;
62(8).
PMID: 29760143
Schistosomiasis is considered the most important disease caused by helminth parasites, in terms of morbidity and mortality. Tools to facilitate gain- and loss-of-function approaches can be expected to precipitate the...
9.
Skinner D, Rinaldi G, Koziol U, Brehm K, Brindley P
Trends Parasitol
. 2014 Feb;
30(3):123-9.
PMID: 24485046
Surveillance by RNA interference is central to controlling the mobilization of transposable elements (TEs). In stem cells, Piwi argonaute (Ago) proteins and associated proteins repress mobilization of TEs to maintain...
10.
Pseudotyped murine leukemia virus for schistosome transgenesis: approaches, methods and perspectives
Mann V, Suttiprapa S, Skinner D, Brindley P, Rinaldi G
Transgenic Res
. 2014 Jan;
23(3):539-56.
PMID: 24474164
Draft genome sequences for the human schistosomes, Schistosoma japonicum, S. mansoni and S. haematobium are now available. The schistosome genome contains ~11,000 protein encoding genes for which the functions of...