Danielle Copmans
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Explore the profile of Danielle Copmans including associated specialties, affiliations and a list of published articles.
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17
Citations
235
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Recent Articles
1.
Modulation of sleep behavior in zebrafish larvae by pharmacological targeting of the orexin receptor
Pardon M, Claes P, Druwe S, Martini M, Siekierska A, Menet C, et al.
Front Pharmacol
. 2022 Nov;
13:1012622.
PMID: 36339591
New pharmacological approaches that target orexin receptors (OXRs) are being developed to treat sleep disorders such as insomnia and narcolepsy, with fewer side effects than existing treatments. Orexins are neuropeptides...
2.
Copmans D, Kildgaard S, Roux E, Partoens M, Steurs G, Wang X, et al.
Pharmaceuticals (Basel)
. 2022 Feb;
15(2).
PMID: 35215359
PharmaSea performed large-scale in vivo screening of marine natural product (MNP) extracts, using zebrafish embryos and larvae, to identify compounds with the potential to treat epilepsy. In this study, we...
3.
Koziol E, Jozwiak K, Budzynska B, de Witte P, Copmans D, Skalicka-Wozniak K
Int J Mol Sci
. 2021 Nov;
22(21).
PMID: 34768849
Coumarins are a well-known group of plant secondary metabolites with various pharmacological activities, including antiseizure activity. In the search for new antiseizure drugs (ASDs) to treat epilepsy, it is yet...
4.
Heylen L, Pham D, De Meulemeester A, Samarut E, Skiba A, Copmans D, et al.
Front Mol Neurosci
. 2021 Nov;
14:753936.
PMID: 34720874
Epilepsy is a common disorder of the brain characterized by spontaneous recurrent seizures, which develop gradually during a process called epileptogenesis. The mechanistic processes underlying the changes of brain tissue...
5.
Wang X, Copmans D, de Witte P
Int J Mol Sci
. 2021 Jul;
22(12).
PMID: 34203824
In drug discovery, often animal models are used that mimic human diseases as closely as possible. These animal models can be used to address various scientific questions, such as testing...
6.
Li J, Nelis M, Sourbron J, Copmans D, Lagae L, Cabooter D, et al.
Neurochem Res
. 2021 May;
46(9):2249-2261.
PMID: 34041623
Dravet syndrome (DS) is a rare genetic encephalopathy that is characterized by severe seizures and highly resistant to commonly used antiepileptic drugs (AEDs). In 2020, FDA has approved fenfluramine (FFA)...
7.
Jansen S, Smlatic E, Copmans D, Debaveye S, Tangy F, Vidalain P, et al.
RNA Biol
. 2021 Jan;
18(5):732-744.
PMID: 33459164
Flaviviruses such as the dengue (DENV) and the Zika virus (ZIKV) are important human pathogens causing around 100 million symptomatic infections each year. During infection, small subgenomic flavivirus RNAs (sfRNAs)...
8.
Li J, Copmans D, Partoens M, Hunyadi B, Luyten W, de Witte P
ACS Chem Neurosci
. 2020 Feb;
11(5):730-742.
PMID: 32083464
With the aim to discover interesting lead compounds that could be further developed into compounds active against pharmacoresistant epilepsies, we first collected 14 medicinal plants used in traditional Chinese medicine...
9.
Copmans D, Kildgaard S, Rasmussen S, Slezak M, Dirkx N, Partoens M, et al.
Mar Drugs
. 2019 Nov;
17(11).
PMID: 31731399
There is a high need for the development of new and improved antiseizure drugs (ASDs) to treat epilepsy. Despite the potential of marine natural products (MNPs), the EU marine biodiscovery...
10.
Liu M, Copmans D, Lu J, Yang M, Sourbron J, Ny A, et al.
J Ethnopharmacol
. 2018 Dec;
232:130-134.
PMID: 30572093
Ethnopharmacological Relevance: Semen Pharbitidis, the seeds of Pharbitis nil (Linn.) Choisy (Convolvulaceae) is a well-known traditional Chinese medicinal plant used for treating helminthiasis and epilepsy in China. Aim Of The...