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Danielle A Jeffrey

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Articles 11
Citations 132
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Recent Articles
1.
Profaci C, Harvey S, Bajc K, Zhang T, Jeffrey D, Zhang A, et al.
Neuron . 2024 Aug; 112(17):2910-2921.e7. PMID: 39142282
Microglia, the resident immune cells of the central nervous system, are intimately involved in the brain's most basic processes, from pruning neural synapses during development to preventing excessive neuronal activity...
2.
Peters C, Singh R, Langley A, Nichols W, Ferris H, Jeffrey D, et al.
Elife . 2024 Apr; 12. PMID: 38652113
Lymphoid restricted membrane protein (LRMP) is a specific regulator of the hyperpolarization-activated cyclic nucleotide-sensitive isoform 4 (HCN4) channel. LRMP prevents cAMP-dependent potentiation of HCN4, but the interaction domains, mechanisms of...
3.
Peters C, Singh R, Langley A, Nichols W, Ferris H, Jeffrey D, et al.
bioRxiv . 2023 Sep; PMID: 37693562
Lymphoid restricted membrane protein (LRMP) is a specific regulator of the hyperpolarization-activated cyclic nucleotide-sensitive isoform 4 (HCN4) channel. LRMP prevents cAMP-dependent potentiation of HCN4 but the interaction domains, mechanisms of...
4.
Jeffrey D, Russell A, Guerrero M, Fontaine J, Romero P, Rosehart A, et al.
bioRxiv . 2023 Aug; PMID: 37645715
Arteries and arterioles exhibit myogenic tone, a partially constricted state that allows further constriction or dilation in response to moment-to-moment fluctuations in blood pressure. The vascular endothelium that lines the...
5.
Jeffrey D, Fontaine J, Dabertrand F
Neurophotonics . 2022 Oct; 9(3):031919. PMID: 36278784
Significance: Vascular mural cells, defined as smooth muscle cells (SMCs) and pericytes, influence brain microcirculation, but how they contribute is not fully understood. Most approaches used to investigate pericyte and...
6.
Jeffrey D, Pires Da Silva J, Garcia A, Jiang X, Karimpour-Fard A, Toni L, et al.
JCI Insight . 2021 Aug; 6(19). PMID: 34383712
Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy and main indication for heart transplantation in children. Therapies specific to pediatric DCM remain limited due to lack of a...
7.
Woulfe K, Jeffrey D, Pires Da Silva J, Wilson C, Mahaffey J, Lau E, et al.
J Mol Cell Cardiol . 2021 Jun; 159:28-37. PMID: 34139234
Aims: Pediatric dilated cardiomyopathy (pDCM) is characterized by unique age-dependent molecular mechanisms that include myocellular responses to therapy. We previously showed that pDCM, but not adult DCM patients respond to...
8.
Garcia A, McPhaul J, Sparagna G, Jeffrey D, Jonscher R, Patel S, et al.
Am J Physiol Heart Circ Physiol . 2020 Feb; 318(4):H787-H800. PMID: 32056460
Despite advances in both medical and surgical therapies, individuals with single ventricle heart disease (SV) remain at high risk for the development of heart failure (HF). However, the molecular mechanisms...
9.
Jeffrey D, Sucharov C
Noncoding RNA Investig . 2018 Sep; 2. PMID: 30198017
No abstract available.
10.
Toni L, Garcia A, Jeffrey D, Jiang X, Stauffer B, Miyamoto S, et al.
MethodsX . 2018 Jul; 5:599-608. PMID: 29984193
Accurate and reliable analysis of gene expression depends on the extraction of pure and high-quality RNA. However, while the conventional phenol-chloroform RNA extraction is preferable over silica-based columns, particularly when...