Daniele Simoneschi
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Explore the profile of Daniele Simoneschi including associated specialties, affiliations and a list of published articles.
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16
Citations
507
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Recent Articles
1.
Garcia-Vazquez N, Gonzalez-Robles T, Lane E, Spasskaya D, Zhang Q, Kerzhnerman M, et al.
bioRxiv
. 2024 Jul;
PMID: 38979260
In healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous...
2.
Rona G, Miwatani-Minter B, Zhang Q, Goldberg H, Kerzhnerman M, Howard J, et al.
Mol Cell
. 2024 Mar;
84(7):1224-1242.e13.
PMID: 38458201
Although mismatch repair (MMR) is essential for correcting DNA replication errors, it can also recognize other lesions, such as oxidized bases. In G0 and G1, MMR is kept in check...
3.
Rona G, Miwatani-Minter B, Zhang Q, Goldberg H, Kerzhnerman M, Howard J, et al.
bioRxiv
. 2024 Jan;
PMID: 38260436
The large majority of oxidative DNA lesions occurring in the G1 phase of the cell cycle are repaired by base excision repair (BER) rather than mismatch repair (MMR) to avoid...
4.
Simoneschi D
Science
. 2022 Nov;
378(6622):845.
PMID: 36423267
AMBRA1 is identified as the long-sought, major controller of D-type cyclins.
5.
Duan S, Moro L, Qu R, Simoneschi D, Cho H, Jiang S, et al.
Cell Rep
. 2021 Oct;
37(3):109870.
PMID: 34686346
FBXO31 is the substrate receptor of one of many CUL1-RING ubiquitin ligase (CRL1) complexes. Here, we show that low FBXO31 mRNA levels are associated with high pre-operative prostate-specific antigen (PSA)...
6.
Chaikovsky A, Sage J, Pagano M, Simoneschi D
DNA Cell Biol
. 2021 Sep;
40(12):1457-1461.
PMID: 34495753
D-type cyclins (cyclin D1, D2, and D3, together cyclin D) are central drivers of the cell division cycle and well-described proto-oncoproteins. Rapid turnover of cyclin D is critical for its...
7.
Simoneschi D, Rona G, Zhou N, Jeong Y, Jiang S, Milletti G, et al.
Nature
. 2021 Apr;
592(7856):789-793.
PMID: 33854235
D-type cyclins are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer, but the mechanisms that regulate their turnover are...
8.
Maiani E, Milletti G, Nazio F, Holdgaard S, Bartkova J, Rizza S, et al.
Nature
. 2021 Apr;
592(7856):799-803.
PMID: 33854232
Mammalian development, adult tissue homeostasis and the avoidance of severe diseases including cancer require a properly orchestrated cell cycle, as well as error-free genome maintenance. The key cell-fate decision to...
9.
10.
Moro L, Simoneschi D, Kurz E, Arbini A, Jang S, Guaragnella N, et al.
Nat Cell Biol
. 2020 Aug;
22(9):1130-1142.
PMID: 32839549
Epigenetic plasticity is a pivotal factor that drives metastasis. Here, we show that the promoter of the gene that encodes the ubiquitin ligase subunit FBXL7 is hypermethylated in advanced prostate...