Daniela Melnik
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Explore the profile of Daniela Melnik including associated specialties, affiliations and a list of published articles.
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19
Citations
311
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Recent Articles
1.
Schulz H, Abdelfattah F, Heinrich A, Melnik D, Sandt V, Kruger M, et al.
Biomolecules
. 2025 Feb;
15(2).
PMID: 40001606
Prostate cancer (PC) is the most diagnosed cancer in males across the globe. Following the formation of metastasis, PC is linked to a notable decline in both prognosis and survival...
2.
Barkia B, Sandt V, Melnik D, Cortes-Sanchez J, Marchal S, Baselet B, et al.
Biomolecules
. 2024 Oct;
14(10).
PMID: 39456226
The formation of tumor spheroids on the random positioning machine (RPM) is a complex and important process, as it enables the study of metastasis ex vivo. However, this process is...
3.
Fluid and Bubble Flow Detach Adherent Cancer Cells to Form Spheroids on a Random Positioning Machine
Cortes-Sanchez J, Melnik D, Sandt V, Kahlert S, Marchal S, Johnson I, et al.
Cells
. 2023 Nov;
12(22).
PMID: 37998400
In preparing space and microgravity experiments, the utilization of ground-based facilities is common for initial experiments and feasibility studies. One approach to simulating microgravity conditions on Earth is to employ...
4.
Melnik D, Cortes-Sanchez J, Sandt V, Kahlert S, Kopp S, Grimm D, et al.
Cancers (Basel)
. 2023 Mar;
15(6).
PMID: 36980530
We recently reported that synthetic glucocorticoid dexamethasone (DEX) is able to suppress metastasis-like spheroid formation in a culture of follicular thyroid cancer (FTC)-133 cells cultured under random positioning. We now...
5.
Sahana J, Cortes-Sanchez J, Sandt V, Melnik D, Corydon T, Schulz H, et al.
Int J Mol Sci
. 2023 Jan;
24(2).
PMID: 36674696
Microgravity changes the gene expression pattern in various cell types. This study focuses on the breast cancer cell lines MCF-7 (less invasive) and MDA-MB-231 (triple-negative, highly invasive). The cells were...
6.
Schulz H, Dietrichs D, Wehland M, Corydon T, Hemmersbach R, Liemersdorf C, et al.
Int J Mol Sci
. 2022 Jul;
23(14).
PMID: 35887223
The high mortality in men with metastatic prostate cancer (PC) establishes the need for diagnostic optimization by new biomarkers. Mindful of the effect of real microgravity on metabolic pathways of...
7.
Dietrichs D, Grimm D, Sahana J, Melnik D, Corydon T, Wehland M, et al.
Front Cell Dev Biol
. 2022 Mar;
10:841017.
PMID: 35252204
Prostate cancer metastasis has an enormous impact on the mortality of cancer patients. Factors involved in cancer progression and metastasis are known to be key players in microgravity (µ)-driven three-dimensional...
8.
Melnik D, Kruger M, Schulz H, Kopp S, Wehland M, Bauer J, et al.
Int J Mol Sci
. 2021 Aug;
22(16).
PMID: 34445479
A spaceflight to the International Space Station (ISS) is a dream of many researchers. We had the chance to investigate the effect of real microgravity (CellBox-2 Space mission) on the...
9.
Sahana J, Corydon T, Wehland M, Kruger M, Kopp S, Melnik D, et al.
Front Cell Dev Biol
. 2021 Jul;
9:672098.
PMID: 34277614
In this study, we evaluated changes in focal adhesions (FAs) in two types of breast cancer cell (BCC) lines (differentiated MCF-7 and the triple-negative MDA-MB-231 cell line) exposed to simulated...
10.
Riwaldt S, Corydon T, Pantalone D, Sahana J, Wise P, Wehland M, et al.
Front Bioeng Biotechnol
. 2021 Jul;
9:679650.
PMID: 34222218
Functioning as the outermost self-renewing protective layer of the human organism, skin protects against a multitude of harmful biological and physical stimuli. Consisting of ectodermal, mesenchymal, and neural crest-derived cell...