Daniela Brunner
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Explore the profile of Daniela Brunner including associated specialties, affiliations and a list of published articles.
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31
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1710
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Recent Articles
1.
Ambesi-Impiombato A, Cox K, Ramboz S, Brunner D, Bansal M, Leahy E
Front Pharmacol
. 2023 Aug;
14:1128562.
PMID: 37560472
Drug-induced Behavioral Signature Analysis (DBSA), is a machine learning (ML) method for screening of compounds, inspired by analytical methods quantifying gene enrichment in genomic analyses. When applied to behavioral data...
2.
Marchionini D, Liu J, Ambesi-Impiombato A, Kerker K, Cirillo K, Bansal M, et al.
JCI Insight
. 2022 Oct;
7(20).
PMID: 36278490
We have developed an inducible Huntington's disease (HD) mouse model that allows temporal control of whole-body allele-specific mutant huntingtin (mHtt) expression. We asked whether moderate global lowering of mHtt (~50%)...
3.
Nguyen L, Leiser S, Song D, Brunner D, Roberds S, Wong M, et al.
Epilepsy Res
. 2022 Feb;
181:106890.
PMID: 35219048
Tuberous sclerosis complex (TSC) is a monogenic disorder characterized by hyperactivation of the mTOR signaling pathway and developmental brain malformations leading to intractable epilepsy. Although treatment with the recently approved...
4.
Urbina F, Zorn K, Brunner D, Ekins S
ACS Chem Neurosci
. 2021 May;
12(12):2247-2253.
PMID: 34028255
The ability to calculate whether small molecules will cross the blood-brain barrier (BBB) is an important task for companies working in neuroscience drug discovery. For a decade, scientists have relied...
5.
Sieberts S, Schaff J, Duda M, Pataki B, Sun M, Snyder P, et al.
NPJ Digit Med
. 2021 Mar;
4(1):53.
PMID: 33742069
Consumer wearables and sensors are a rich source of data about patients' daily disease and symptom burden, particularly in the case of movement disorders like Parkinson's disease (PD). However, interpreting...
6.
Mahnert A, Verseux C, Schwendner P, Koskinen K, Kumpitsch C, Blohs M, et al.
Microbiome
. 2021 Jan;
9(1):27.
PMID: 33487169
Background: Human health is closely interconnected with its microbiome. Resilient microbiomes in, on, and around the human body will be key for safe and successful long-term space travel. However, longitudinal...
7.
Theilmann W, Gericke B, Schidlitzki A, Anjum S, Borsdorf S, Harries T, et al.
Neuropharmacology
. 2020 Sep;
180:108297.
PMID: 32890589
Mechanistic target of rapamycin (mTOR) regulates cell proliferation, growth and survival, and is activated in cancer and neurological disorders, including epilepsy. The rapamycin derivative ("rapalog") everolimus, which allosterically inhibits the...
8.
Kabitzke P, Morales D, He D, Cox K, Sutphen J, Thiede L, et al.
Genes Brain Behav
. 2020 May;
19(7):e12676.
PMID: 32445272
Phenotyping mouse model systems of human disease has proven to be a difficult task, with frequent poor inter- and intra-laboratory replicability, particularly in behavioral domains such as social and cognitive...
9.
Benraiss A, Wang S, Herrlinger S, Li X, Chandler-Militello D, Mauceri J, et al.
Nat Commun
. 2016 Jun;
7:11758.
PMID: 27273432
The causal contribution of glial pathology to Huntington disease (HD) has not been heavily explored. To define the contribution of glia to HD, we established human HD glial chimeras by...
10.
Curtin P, Farrar A, Oakeshott S, Sutphen J, Berger J, Mazzella M, et al.
Front Behav Neurosci
. 2016 Jan;
9:361.
PMID: 26793080
Huntington's Disease (HD) is a progressive neurodegenerative disorder that causes motor, cognitive, and psychiatric symptoms. In these experiments, we tested if operant training at an early age affected adult cognitive...