Daniel Paull
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Explore the profile of Daniel Paull including associated specialties, affiliations and a list of published articles.
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42
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1428
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Recent Articles
11.
Han Y, Tan L, Zhou T, Yang L, Carrau L, Lacko L, et al.
Cell Stem Cell
. 2022 Oct;
29(10):1475-1490.e6.
PMID: 36206731
Population-based studies to identify disease-associated risk alleles typically require samples from a large number of individuals. Here, we report a human-induced pluripotent stem cell (hiPSC)-based screening strategy to link human...
12.
Hall J, Paull D, Pebay A, Lidgerwood G
Clin Exp Ophthalmol
. 2022 Jun;
50(6):667-677.
PMID: 35739648
Human pluripotent stem cells (hPSCs), which include induced pluripotent stem cells and embryonic stem cells, are powerful tools for studying human development, physiology and disease, including those affecting the retina....
13.
Smith M, Chamling X, Gill A, Martinez H, Li W, Fitzgerald K, et al.
Front Mol Neurosci
. 2022 May;
15:874299.
PMID: 35600072
Astrocytes are instrumental in maintaining central nervous system (CNS) homeostasis and responding to injury. A major limitation of studying neurodegenerative diseases like multiple sclerosis (MS) is lack of human pathological...
14.
Ghazizadeh Z, Zhu J, Fattahi F, Tang A, Sun X, Amin S, et al.
iScience
. 2022 Apr;
25(4):104153.
PMID: 35434558
The sinoatrial node (SAN) is the primary pacemaker of the heart. The human SAN is poorly understood due to limited primary tissue access and limitations in robust derivation methods. We...
15.
Schiff L, Migliori B, Chen Y, Carter D, Bonilla C, Hall J, et al.
Nat Commun
. 2022 Mar;
13(1):1590.
PMID: 35338121
Drug discovery for diseases such as Parkinson's disease are impeded by the lack of screenable cellular phenotypes. We present an unbiased phenotypic profiling platform that combines automated cell culture, high-content...
16.
Lagomarsino V, Pearse 2nd R, Liu L, Hsieh Y, Fernandez M, Vinton E, et al.
Neuron
. 2021 Sep;
109(21):3402-3420.e9.
PMID: 34473944
We have generated a controlled and manipulable resource that captures genetic risk for Alzheimer's disease: iPSC lines from 53 individuals coupled with RNA and proteomic profiling of both iPSC-derived neurons...
17.
Cai H, Gong J, Noggle S, Paull D, Rizzolo L, Del Priore L, et al.
Exp Eye Res
. 2021 Apr;
207:108576.
PMID: 33895162
We have reported previously that retinal pigment epithelium (RPE) differentiated from induced pluripotent stem cells (iPSC) generated from fibroblasts of patients with age-related macular degeneration (AMD) exhibit a retinal degenerative...
18.
Gong J, Cai H, Noggle S, Paull D, Rizzolo L, Del Priore L, et al.
Stem Cells Transl Med
. 2019 Dec;
9(3):364-376.
PMID: 31840941
Modeling age-related macular degeneration (AMD) is challenging, because it is a multifactorial disease. To focus on interactions between the retinal pigment epithelium (RPE) and Bruch's membrane, we generated RPE from...
19.
Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
Cornacchia D, Zhang C, Zimmer B, Chung S, Fan Y, Soliman M, et al.
Cell Stem Cell
. 2019 Jun;
25(1):120-136.e10.
PMID: 31155483
Current challenges in capturing naive human pluripotent stem cells (hPSCs) suggest that the factors regulating human naive versus primed pluripotency remain incompletely defined. Here we demonstrate that the widely used...
20.
Cai H, Gong J, Abriola L, Hoyer D, Nyscf Global Stem Cell Array Team , Noggle S, et al.
Exp Eye Res
. 2019 Apr;
185:107641.
PMID: 30980814
Dysfunction and eventual loss of retinal pigment epithelial (RPE) cells is a hallmark of atrophic age-related macular degeneration (AMD), and linked to oxidative and nitrosative damage. Herein, we use a...