Daniel P MacEachran
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Explore the profile of Daniel P MacEachran including associated specialties, affiliations and a list of published articles.
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11
Citations
681
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Recent Articles
1.
MacEachran D, Sinskey A
Microb Cell Fact
. 2013 Nov;
12:104.
PMID: 24209886
Background: The Gram-positive actinomycete Rhodococcus opacus is widely studied for its innate ability to store large amounts of carbon in the form of triacylglycerol (TAG). Several groups have demonstrated that...
2.
Kurosawa K, MacEachran D, Sinskey A
Expert Opin Drug Discov
. 2012 Jul;
5(9):819-25.
PMID: 22823257
Bacteria obtain a significant proportion of their genetic diversity via acquisition of DNA from distantly related organisms, a phenomenon known as horizontal gene transfer. The focus of horizontal gene transfer...
3.
Bomberger J, Ye S, MacEachran D, Koeppen K, Barnaby R, OToole G, et al.
PLoS Pathog
. 2011 Apr;
7(3):e1001325.
PMID: 21455491
Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen chronically infecting the lungs of patients with chronic obstructive pulmonary disease (COPD), pneumonia, cystic fibrosis (CF), and bronchiectasis. Cif (PA2934), a bacterial...
4.
MacEachran D, Prophete M, Sinskey A
Appl Environ Microbiol
. 2010 Sep;
76(21):7217-25.
PMID: 20851968
Generally, prokaryotes store carbon as polyhydroxyalkanoate, starch, or glycogen. The Gram-positive actinomycete Rhodococcus opacus strain PD630 is noteworthy in that it stores carbon in the form of triacylglycerol (TAG). Several...
5.
Bahl C, MacEachran D, OToole G, Madden D
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2010 Jan;
66(Pt 1):26-8.
PMID: 20057063
The opportunistic pathogen Pseudomonas aeruginosa secretes a protein that triggers the accelerated degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells. This protein, which is known...
6.
Shanks R, Kadouri D, MacEachran D, OToole G
Plasmid
. 2009 May;
62(2):88-97.
PMID: 19477196
Recombineering with Saccharomyces cerevisiae is a powerful methodology that can be used to clone multiple unmarked pieces of DNA to generate complex constructs with high efficiency. Here, we introduce two...
7.
Bomberger J, MacEachran D, Coutermarsh B, Ye S, OToole G, Stanton B
PLoS Pathog
. 2009 Apr;
5(4):e1000382.
PMID: 19360133
Bacteria use a variety of secreted virulence factors to manipulate host cells, thereby causing significant morbidity and mortality. We report a mechanism for the long-distance delivery of multiple bacterial virulence...
8.
Ye S, MacEachran D, Hamilton J, OToole G, Stanton B
Am J Physiol Cell Physiol
. 2008 Jul;
295(3):C807-18.
PMID: 18650266
P-glycoprotein (Pgp), a member of the adenosine triphosphate-binding cassette (ABC) transporter superfamily, is a major drug efflux pump expressed in normal tissues, and is overexpressed in many human cancers. Overexpression...
9.
MacEachran D, Stanton B, OToole G
Infect Immun
. 2008 May;
76(7):3197-206.
PMID: 18458065
We previously reported that the novel Pseudomonas aeruginosa toxin Cif is capable of decreasing apical membrane expression of the cystic fibrosis transmembrane conductance regulator (CFTR). We further demonstrated that Cif...
10.
MacEachran D, Ye S, Bomberger J, Hogan D, Swiatecka-Urban A, Stanton B, et al.
Infect Immun
. 2007 May;
75(8):3902-12.
PMID: 17502391
We previously reported that Pseudomonas aeruginosa PA14 secretes a protein that can reduce the apical membrane expression of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Here we report that...