Daniel N Mitroi
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Explore the profile of Daniel N Mitroi including associated specialties, affiliations and a list of published articles.
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9
Citations
187
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Recent Articles
1.
Toledano-Zaragoza A, Enriquez-Zarralanga V, Naya-Forcano S, Briz V, Alfaro-Ruiz R, Parra-Martinez M, et al.
Cell Death Dis
. 2024 Oct;
15(10):771.
PMID: 39443481
Niemann-Pick disease Type C (NPC) is caused by mutations in the cholesterol transport protein NPC1 leading to the endolysosomal accumulation of the lipid and to psychiatric alterations. Using an NPC...
2.
Gheorghe S, Stan M, Mitroi D, Staicu A, Cicirma M, Lucaciu I, et al.
Toxics
. 2022 May;
10(5).
PMID: 35622641
One cationic surfactant with a wide spectrum of microbiocidal activity is benzethonium chloride (BEC). Despite being widely used, the toxicity data on vertebrate organisms are limited. Therefore, we aimed to...
3.
Mitroi D, Tian M, Kawaguchi R, Lowry W, Carmichael S
J Cell Mol Med
. 2022 May;
26(11):3183-3195.
PMID: 35543222
Background: Vascular dementia (VaD) is the accumulation of vascular lesions in the subcortical white matter of the brain. These lesions progress and there is no direct medical therapy. Aims: To...
4.
Kalinichenko L, Muhle C, Jia T, Anderheiden F, Datz M, Eberle A, et al.
Cereb Cortex
. 2022 Mar;
33(3):844-864.
PMID: 35296883
Alcohol use, abuse, and addiction, and resulting health hazards are highly sex-dependent with unknown mechanisms. Previously, strong links between the SMPD3 gene and its coded protein neutral sphingomyelinase 2 (NSM)...
5.
Kalinichenko L, Muhle C, Jia T, Anderheiden F, Datz M, Eberle A, et al.
Mol Psychiatry
. 2021 Sep;
26(12):7403-7416.
PMID: 34584229
Mental disorders are highly comorbid and occur together with physical diseases, which are often considered to arise from separate pathogenic pathways. We observed in alcohol-dependent patients increased serum activity of...
6.
Mitroi D, Pereyra-Gomez G, Soto-Huelin B, Senovilla F, Kobayashi T, Esteban J, et al.
EMBO Rep
. 2019 Sep;
20(11):e48143.
PMID: 31535451
NPC is a neurodegenerative disorder characterized by cholesterol accumulation in endolysosomal compartments. It is caused by mutations in the gene encoding NPC1, an endolysosomal protein mediating intracellular cholesterol trafficking. Cognitive...
7.
Gabande-Rodriguez E, Perez-Canamas A, Soto-Huelin B, Mitroi D, Sanchez-Redondo S, Martinez-Saez E, et al.
EMBO J
. 2018 Dec;
38(2).
PMID: 30530526
Neuropathic lysosomal storage disorders (LSDs) present with activated pro-inflammatory microglia. However, anti-inflammatory treatment failed to improve disease pathology. We characterise the mechanisms underlying microglia activation in Niemann-Pick disease type A...
8.
Mitroi D, Karunakaran I, Graler M, Saba J, Ehninger D, Ledesma M, et al.
Autophagy
. 2017 May;
13(5):885-899.
PMID: 28521611
Macroautophagy/autophagy defects have been identified as critical factors underlying the pathogenesis of neurodegenerative diseases. The roles of the bioactive signaling lipid sphingosine-1-phosphate (S1P) and its catabolic enzyme SGPL1/SPL (sphingosine phosphate...
9.
Mitroi D, Deutschmann A, Raucamp M, Karunakaran I, Glebov K, Hans M, et al.
Sci Rep
. 2016 Nov;
6:37064.
PMID: 27883090
The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons. We have shown previously that neuronal S1P accumulation is toxic leading to...