Daniel L Faden
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Explore the profile of Daniel L Faden including associated specialties, affiliations and a list of published articles.
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68
Citations
602
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Recent Articles
1.
Sim E, Rhoades J, Xiong K, Walsh L, Crnjac A, Blewett T, et al.
medRxiv
. 2025 Feb;
PMID: 39974077
Purpose: While circulating tumor DNA (ctDNA) is a promising biomarker for minimal residual disease (MRD) detection in head and neck squamous cell carcinoma (HNSCC), more sensitive assays are needed for...
2.
Ruiz-Torres D, Merkin R, Bryan M, Mendel J, Efthymiou V, Roberts T, et al.
medRxiv
. 2025 Feb;
PMID: 39973993
Background: Recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) is an aggressive cancer with a median overall survival of only 12 months. Existing biomarkers have limited ability to predict...
3.
Ruiz-Torres D, Bryan M, Hirayama S, Merkin R, Luciani E, Roberts T, et al.
Oncoimmunology
. 2025 Feb;
14(1):2466308.
PMID: 39963988
Immune checkpoint blockade (ICB) is the standard of care for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), yet efficacy remains low. The combined positive score (CPS) for PD-L1 is...
4.
Nikitina A, Kiriy D, Tyshevich A, Tychinin D, Antysheva Z, Sobol A, et al.
Viruses
. 2025 Jan;
17(1).
PMID: 39861794
Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HPV-positive HNSCC) has distinct biological characteristics from HPV-negative HNSCC. Using an AI-based analytical platform on meta cohorts, we profiled expression patterns...
5.
Ruiz-Torres D, Wise J, Zhao B, Oliveira-Costa J, Cavallaro S, Sadow P, et al.
Front Immunol
. 2024 Dec;
15():1440530.
PMID: 39697344
The potent immunostimulatory effects of toll-like receptor 8 (TLR8) agonism in combination with PD-1 blockade have resulted in various preclinical investigations, yet the mechanism of action in humans remains unknown....
6.
Zhao B, Hirayama S, Goss D, Zhao Y, Faden D
Oral Oncol
. 2024 Oct;
159:107057.
PMID: 39383626
Objective: Human papillomavirus (HPV) is known to affect head and neck sites beyond the oropharynx, including the nasopharynx. Unlike HPV-associated oropharyngeal squamous cell carcinoma (HPV+OPSCC), HPV-associated nasopharyngeal carcinoma (HPV+NPC) is...
7.
Ruiz-Torres D, Bryan M, Hirayama S, Merkin R, Luciani E, Roberts T, et al.
medRxiv
. 2024 Sep;
PMID: 39314968
Methods: Pre-ICB tumor tissue sections were obtained from 9 responders (complete response, partial response, or stable disease) and 11 non-responders (progressive disease) classified via RECISTv1.1. A custom multi-immunofluorescence (mIF) staining...
8.
Zhao B, Hirayama S, Goss D, Zhao Y, Faden D
medRxiv
. 2024 Sep;
PMID: 39314950
Objective: Human papillomavirus (HPV) is known to affect head and neck sites beyond the oropharynx, including the nasopharynx. Unlike HPV-associated oropharyngeal squamous cell carcinoma (HPV+OPSCC), HPV-associated nasopharyngeal carcinoma (HPV+NPC) is...
9.
Ruiz-Torres D, Wise J, Zhao B, Oliveira-Costa J, Cavallaro S, Sadow P, et al.
bioRxiv
. 2024 Sep;
PMID: 39282367
The potent immunostimulatory effects of toll-like receptor 8 (TLR8) agonism in combination with PD-1 blockade have resulted in various preclinical investigations, yet the mechanism of action in humans remains unknown....
10.
Zamuner F, Gunti S, Starrett G, Faraji F, Toni T, Saraswathula A, et al.
bioRxiv
. 2024 Jul;
PMID: 38979305
One Sentence Summary: This study solidifies HPV as a driver of HPV-associated SNSCC tumorigenesis, identifies molecular mechanisms distinguishing HPV-associated and HPV-independent SNSCC, and elucidates YAP/TAZ and PI3K blockade as key...