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Daniel Janman

Explore the profile of Daniel Janman including associated specialties, affiliations and a list of published articles. Areas
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Articles 5
Citations 193
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Recent Articles
1.
Kennedy A, Waters E, Rowshanravan B, Hinze C, Williams C, Janman D, et al.
Nat Immunol . 2022 Aug; 23(9):1365-1378. PMID: 35999394
CD28 and CTLA-4 (CD152) play essential roles in regulating T cell immunity, balancing the activation and inhibition of T cell responses, respectively. Although both receptors share the same ligands, CD80...
2.
Janman D, Hinze C, Kennedy A, Halliday N, Waters E, Williams C, et al.
Immunology . 2021 May; 164(1):106-119. PMID: 33960403
CTLA-4 is an essential regulator of T-cell immune responses whose intracellular trafficking is a hallmark of its expression. Defects in CTLA-4 trafficking due to LRBA deficiency cause profound autoimmunity in...
3.
Soskic B, Jeffery L, Kennedy A, Gardner D, Hou T, Halliday N, et al.
Front Immunol . 2021 Jan; 11:577655. PMID: 33488578
CD80 and CD86 are expressed on antigen presenting cells (APCs) and their role in providing costimulation to T cells is well established. However, it has been shown that these molecules...
4.
Halliday N, Williams C, Kennedy A, Waters E, Pesenacker A, Soskic B, et al.
Front Immunol . 2020 Dec; 11:600000. PMID: 33363541
CD80 and CD86 are expressed on antigen presenting cells and are required to engage their shared receptor, CD28, for the costimulation of CD4 T cells. It is unclear why two...
5.
Hou T, Verma N, Wanders J, Kennedy A, Soskic B, Janman D, et al.
Blood . 2017 Feb; 129(11):1458-1468. PMID: 28159733
Heterozygous CTLA-4 deficiency has been reported as a monogenic cause of common variable immune deficiency with features of immune dysregulation. Direct mutation in CTLA-4 leads to defective regulatory T-cell (Treg)...