Daniel J Bumbarger
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Explore the profile of Daniel J Bumbarger including associated specialties, affiliations and a list of published articles.
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20
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441
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Recent Articles
1.
Dorkenwald S, Schneider-Mizell C, Brittain D, Halageri A, Jordan C, Kemnitz N, et al.
bioRxiv
. 2023 Aug;
PMID: 37546753
Advances in Electron Microscopy, image segmentation and computational infrastructure have given rise to large-scale and richly annotated connectomic datasets which are increasingly shared across communities. To enable collaboration, users need...
2.
Ding Z, Fahey P, Papadopoulos S, Wang E, Celii B, Papadopoulos C, et al.
bioRxiv
. 2023 Mar;
PMID: 36993398
Understanding the relationship between circuit connectivity and function is crucial for uncovering how the brain implements computation. In the mouse primary visual cortex (V1), excitatory neurons with similar response properties...
3.
Celii B, Papadopoulos S, Ding Z, Fahey P, Wang E, Papadopoulos C, et al.
bioRxiv
. 2023 Mar;
PMID: 36993282
We are now in the era of millimeter-scale electron microscopy (EM) volumes collected at nanometer resolution. Dense reconstruction of cellular compartments in these EM volumes has been enabled by recent...
4.
Schneider-Mizell C, Bodor A, Brittain D, Buchanan J, Bumbarger D, Elabbady L, et al.
bioRxiv
. 2023 Feb;
PMID: 36747710
Mammalian cortex features a vast diversity of neuronal cell types, each with characteristic anatomical, molecular and functional properties. Synaptic connectivity powerfully shapes how each cell type participates in the cortical...
5.
Buchanan J, Elabbady L, Collman F, Jorstad N, Bakken T, Ott C, et al.
Proc Natl Acad Sci U S A
. 2022 Nov;
119(48):e2202580119.
PMID: 36417438
Neurons in the developing brain undergo extensive structural refinement as nascent circuits adopt their mature form. This physical transformation of neurons is facilitated by the engulfment and degradation of axonal...
6.
Dorkenwald S, Turner N, Macrina T, Lee K, Lu R, Wu J, et al.
Elife
. 2022 Nov;
11.
PMID: 36382887
Learning from experience depends at least in part on changes in neuronal connections. We present the largest map of connectivity to date between cortical neurons of a defined type (layer...
7.
Mahalingam G, Torres R, Kapner D, Trautman E, Fliss T, Seshamani S, et al.
Elife
. 2022 Jul;
11.
PMID: 35880860
Serial-section electron microscopy (ssEM) is the method of choice for studying macroscopic biological samples at extremely high resolution in three dimensions. In the nervous system, nanometer-scale images are necessary to...
8.
Turner N, Macrina T, Bae J, Yang R, Wilson A, Schneider-Mizell C, et al.
Cell
. 2022 Feb;
185(6):1082-1100.e24.
PMID: 35216674
We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from ∼250 × 140 × 90 μm of electron microscopic images, including pyramidal and non-pyramidal neurons, astrocytes, microglia, oligodendrocytes...
9.
Schneider-Mizell C, Bodor A, Collman F, Brittain D, Bleckert A, Dorkenwald S, et al.
Elife
. 2021 Dec;
10.
PMID: 34851292
Inhibitory neurons in mammalian cortex exhibit diverse physiological, morphological, molecular, and connectivity signatures. While considerable work has measured the average connectivity of several interneuron classes, there remains a fundamental lack...
10.
Yin W, Brittain D, Borseth J, Scott M, Williams D, Perkins J, et al.
Nat Commun
. 2020 Oct;
11(1):4949.
PMID: 33009388
Electron microscopy (EM) is widely used for studying cellular structure and network connectivity in the brain. We have built a parallel imaging pipeline using transmission electron microscopes that scales this...