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Daniel Irelan

Explore the profile of Daniel Irelan including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Irelan D, Boyd A, Fiedler E, Lochmaier P, McDonough W, Aragon I, et al.
Int J Mol Sci . 2023 Feb; 24(4). PMID: 36834669
cAMP-phosphodiesterase 4 (PDE4) inhibitors are currently approved for the treatment of inflammatory diseases. There is interest in expanding the therapeutic application of PDE4 inhibitors to metabolic disorders, as their chronic...
2.
Boyd A, Lochmaier P, Irelan D, Fiedler E, Lee J, Fouty B, et al.
Biology (Basel) . 2022 Nov; 11(11). PMID: 36358283
The analysis of blood samples from mice treated with the PDE4 inhibitor Roflumilast revealed an unexpected reduction in serum potassium levels, while sodium and chloride levels were unaffected. Treatment with...
3.
Boyd A, Aragon I, Rich J, McDonough W, Oditt M, Irelan D, et al.
Biology (Basel) . 2021 Dec; 10(12). PMID: 34943270
Treatment with PAN-PDE4 inhibitors has been shown to produce hypothermia in multiple species. Given the growing body of evidence that links nausea and emesis to disturbances in thermoregulation in mammals,...