Daniel I R Spencer
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Explore the profile of Daniel I R Spencer including associated specialties, affiliations and a list of published articles.
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58
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1247
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Recent Articles
1.
Bax H, Chauhan J, McCraw A, Grandits M, Stavraka C, Lentfer H, et al.
MAbs
. 2025 Jan;
17(1):2451295.
PMID: 39833133
Antibodies used for cancer therapy are monoclonal IgGs, but tumor-targeting IgE antibodies have shown enhanced effector cell potency against cancer in preclinical models. Research-grade recombinant IgE antibodies have been generated...
2.
Soliman M, Martinez-Serra A, Dobricic M, Trinh D, Cheeseman J, Spencer D, et al.
Front Toxicol
. 2024 Aug;
6:1393330.
PMID: 39109300
Engineered nanoparticles (NPs) pose a broad spectrum of interesting properties that make them useful for many applications. However, continuous exposure to NPs requires the need to deeply understand the outcomes...
3.
McCraw A, Palhares L, Hendel J, Gardner R, Santaolalla A, Crescioli S, et al.
Allergy
. 2024 Aug;
79(10):2625-2661.
PMID: 39099223
The impact of human IgE glycosylation on structure, function and disease mechanisms is not fully elucidated, and heterogeneity in different studies renders drawing conclusions challenging. Previous reviews discussed IgE glycosylation...
4.
Martinez Gascuena A, Wu H, Wang R, Owen C, Hernando P, Monaco S, et al.
Commun Chem
. 2024 Jun;
7(1):137.
PMID: 38890439
Microbial α-L-fucosidases catalyse the hydrolysis of terminal α-L-fucosidic linkages and can perform transglycosylation reactions. Based on sequence identity, α-L-fucosidases are classified in glycoside hydrolases (GHs) families of the carbohydrate-active enzyme...
5.
OFlaherty R, Amez Martin M, Gardner R, Jennings P, Rudd P, Spencer D, et al.
Biomolecules
. 2024 Jan;
14(1).
PMID: 38254725
Recombinant human erythropoietin (EPO) is a biopharmaceutical frequently used in the treatment of anemia. It is a heavily glycosylated protein with a diverse and complex glycome. EPO -glycosylation influences important...
6.
Cheeseman J, Badia C, Elgood-Hunt G, Gardner R, Trinh D, Monopoli M, et al.
Glycoconj J
. 2023 Nov;
40(6):645-654.
PMID: 37991561
Cardiovascular disease (CVD) is a group of health conditions affecting the heart and vascular system with very high prevalence and mortality rates. The presence of CVD is characterised by high...
7.
Moran A, Elgood-Hunt G, van der Burgt Y, Wuhrer M, Mesker W, Tollenaar R, et al.
Biomolecules
. 2023 Jun;
13(6).
PMID: 37371476
A newly developed analytical strategy was applied to profile the total serum -glycome of 64 colorectal cancer (CRC) patients before and after surgical intervention. In this cohort, it was previously...
8.
Shubhakar A, Jansen B, Adams A, Reiding K, Ventham N, Kalla R, et al.
J Crohns Colitis
. 2023 Jan;
17(6):919-932.
PMID: 36694402
Biomarkers to guide clinical decision making at diagnosis of inflammatory bowel disease [IBD] are urgently needed. We investigated a composite serum N-glycomic biomarker to predict future disease course in a...
9.
McCraw A, Gardner R, Davies A, Spencer D, Grandits M, Wagner G, et al.
Int J Mol Sci
. 2022 Nov;
23(21).
PMID: 36362241
Efficient characterization of IgE antibodies and their glycan structures is required for understanding their function in allergy and in the emerging AllergoOncology field for antibody immunotherapy. We report the generation,...
10.
Crouch L, Urbanowicz P, Basle A, Cai Z, Liu L, Voglmeir J, et al.
Proc Natl Acad Sci U S A
. 2022 Sep;
119(39):e2208168119.
PMID: 36122227
The major nutrients available to the human colonic microbiota are complex glycans derived from the diet. To degrade this highly variable mix of sugar structures, gut microbes have acquired a...