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Daniel H Mathalon

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Articles 368
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Recent Articles
11.
Hamilton H, Roach B, Bachman P, Belger A, Carrion R, Duncan E, et al.
Clin EEG Neurosci . 2024 Nov; 56(1):46-59. PMID: 39552576
Mismatch negativity (MMN) event-related potential (ERP) component reduction, indexing N-methyl-D-aspartate receptor (NMDAR)-dependent auditory echoic memory and short-term plasticity, is a well-established biomarker of schizophrenia that is sensitive to psychosis risk...
12.
Cadenhead K, Addington J, Bearden C, Cannon T, Cornblatt B, Keshavan M, et al.
Schizophr Bull . 2024 Nov; PMID: 39488001
Background And Hypothesis: Studying individuals at Clinical High Risk (CHR) for psychosis provides an opportunity to examine protective factors that predict resilient outcomes. Here, we present a model for the...
13.
Ku B, Yuan Q, Haardorfer R, Addington J, Bearden C, Cadenhead K, et al.
Psychiatry Res . 2024 Oct; 342:116222. PMID: 39378539
Neighborhood ethnoracial composition has been associated with schizophrenia, but mechanisms are unclear. This study investigates the moderators and mediators of the association between neighborhood ethnoracial diversity and positive symptoms among...
14.
Giampetruzzi E, Walker E, Addington J, Bearden C, Cadenhead K, Cannon T, et al.
Psychiatry Res . 2024 Oct; 342:116214. PMID: 39368239
Introduction: Research has established that adverse childhood experiences (ACEs) confer risk for psychiatric diagnoses, and that protective factors moderate this association. Investigation into the effect of protective factors in the...
15.
Deng W, Chong B, Addington J, Bearden C, Cadenhead K, Cornblatt B, et al.
Biol Psychiatry Cogn Neurosci Neuroimaging . 2024 Sep; 10(2):195-202. PMID: 39260565
Background: Although the clinical high risk for psychosis (CHR-P) criteria are widely used to ascertain individuals at heightened risk for imminent onset of psychosis, it remains controversial whether CHR-P status...
16.
Etkin A, Mathalon D
JAMA Psychiatry . 2024 Sep; 81(11):1142-1147. PMID: 39230917
Importance: Advancing precision psychiatry, where treatments are based on an individual's biology rather than solely their clinical presentation, requires attention to several key attributes for any candidate biomarker. These include...
17.
Forsyth J, Zhu J, Chavannes A, Trevorrow Z, Hyat M, Sievertsen S, et al.
medRxiv . 2024 Aug; PMID: 39211869
Schizophrenia spectrum disorders (SSDs) are characterized by substantial clinical and genetic heterogeneity. Multiple recurrent copy number variants (CNVs) increase risk for SSDs; however, how known risk CNVs and broader genome-wide...
18.
Yassin W, Green J, Keshavan M, Del Re E, Addington J, Bearden C, et al.
medRxiv . 2024 Aug; PMID: 39211862
Introduction: Schizophrenia is a mental health condition that severely impacts well-being. Cognitive impairment is among its core features, often presenting well before the onset of overt psychosis, underscoring a critical...
19.
Cohen S, Goldsmith D, Ning C, Addington J, Bearden C, Cadenhead K, et al.
Psychiatry Res . 2024 Aug; 341:116147. PMID: 39197223
Insomnia and suicidal ideation (SI) are common in schizophrenia, including in individuals at clinical high-risk for psychosis (CHR-P). Previous studies have found associations between sleep disturbance, SI, and psychopathology in...
20.
Schleifer C, Chang S, Amir C, OHora K, Fung H, Kang J, et al.
Biol Psychiatry . 2024 Aug; 97(2):178-187. PMID: 39181389
Background: 22q11.2 deletion syndrome (22qDel) is a copy number variant that is associated with psychosis and other neurodevelopmental disorders. Adolescents who are at clinical high risk for psychosis (CHR) are...