Daniel G W Alanine
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Explore the profile of Daniel G W Alanine including associated specialties, affiliations and a list of published articles.
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13
Citations
523
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Recent Articles
1.
Williams B, King L, Pulido D, Quinkert D, Lias A, Silk S, et al.
Nat Commun
. 2024 Jun;
15(1):4857.
PMID: 38849365
Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) and RH5-interacting protein (RIPR) to form an essential heterotrimeric "RCR-complex". We...
2.
Ragotte R, Pulido D, Lias A, Quinkert D, Alanine D, Jamwal A, et al.
Nat Commun
. 2022 Feb;
13(1):933.
PMID: 35177602
Understanding mechanisms of antibody synergy is important for vaccine design and antibody cocktail development. Examples of synergy between antibodies are well-documented, but the mechanisms underlying these relationships often remain poorly...
3.
Willcox A, Huber A, Diouf A, Barrett J, Silk S, Pulido D, et al.
Cell Rep Med
. 2021 Aug;
2(7):100326.
PMID: 34337556
Reticulocyte-binding protein homolog 5 (RH5) is a leading blood-stage vaccine candidate. Another possible candidate, apical membrane antigen 1 (AMA1), was not efficacious in malaria-endemic populations, likely due to pre-existing antimalarial...
4.
Ali E, Kalli M, Wan D, Nakamura R, Onion D, Alanine D, et al.
PLoS One
. 2019 Aug;
14(8):e0221034.
PMID: 31430311
Several laboratories have created rat basophil leukemia (RBL) cell lines stably transfected with the human high affinity IgE receptor (FcεRIH). More recently, humanized RBL cell lines saw the introduction of...
5.
Alanine D, Quinkert D, Kumarasingha R, Mehmood S, Donnellan F, Minkah N, et al.
Cell
. 2019 Jun;
178(1):216-228.e21.
PMID: 31204103
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines against the disease-causing blood-stage of malaria. However, little is known about how human antibodies confer...
6.
Rawlinson T, Barber N, Mohring F, Cho J, Kosaisavee V, Gerard S, et al.
Nat Microbiol
. 2019 May;
4(9):1497-1507.
PMID: 31133755
The most widespread form of malaria is caused by Plasmodium vivax. To replicate, this parasite must invade immature red blood cells through a process requiring interaction of the P. vivax...
7.
Douglas A, Baldeviano G, Jin J, Miura K, Diouf A, Zenonos Z, et al.
Nat Commun
. 2019 Apr;
10(1):1953.
PMID: 31028254
Malaria vaccine design and prioritization has been hindered by the lack of a mechanistic correlate of protection. We previously demonstrated a strong association between protection and merozoite-neutralizing antibody responses following...
8.
Foquet L, Schafer C, Minkah N, Alanine D, Flannery E, Steel R, et al.
Front Immunol
. 2018 Mar;
9:524.
PMID: 29593746
The invention of liver-humanized mouse models has made it possible to directly study the preerythrocytic stages of . In contrast, the current models to directly study blood stage infection are...
9.
Nikolaeva D, Illingworth J, Miura K, Alanine D, Brian I, Li Y, et al.
Mol Cell Proteomics
. 2017 Nov;
19(1):155-166.
PMID: 29089373
malaria continues to evade control efforts, utilizing highly specialized sexual-stages to transmit infection between the human host and mosquito vector. In a vaccination model, antibodies directed to sexual-stage antigens, when...
10.
Hjerrild K, Jin J, Wright K, Brown R, Marshall J, Labbe G, et al.
Sci Rep
. 2016 Jul;
6:30357.
PMID: 27457156
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. However it has proved challenging to identify a...