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Daniel E Conway

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Recent Articles
1.
Tran S, Lichtenberg J, Leonard C, Williamson J, Sterling H, Panek G, et al.
iScience . 2025 Feb; 28(2):111844. PMID: 39981519
During epithelial morphogenesis, , epithelial cells form cysts enclosing a single, hollow lumen and extend protrusions as a precursor for tubulogenesis Cell-cell adhesions (e.g., cadherins) contribute to successful execution of...
2.
Tieu K, Espey M, Narayanan A, Heise R, Alem F, Conway D
Sci Rep . 2025 Jan; 15(1):3549. PMID: 39875448
SARS-CoV-2 is a viral infection, best studied in the context of epithelial cell infection. Epithelial cells, when infected with SARS-CoV-2 express the viral S-protein, which causes host cells to fuse...
3.
Tervonen A, Leclerc S, Ruokolainen V, Tieu K, Lyonnais S, Niskanen H, et al.
bioRxiv . 2025 Jan; PMID: 39803437
Mechanical properties of the nucleus are remodeled not only by extracellular forces transmitted to the nucleus but also by internal modifications, such as those induced by viral infections. During herpes...
4.
Wang T, Abolghasemzade S, McKee B, Singh I, Pendyala K, Mohajeri M, et al.
Nat Commun . 2024 Nov; 15(1):10151. PMID: 39578439
Extracellular matrix (ECM) stiffness influences cancer cell fate by altering gene expression. Previous studies suggest that stiffness-induced nuclear deformation may regulate gene expression through YAP nuclear localization. We investigated the...
5.
Jin X, Rosenbohm J, Moghaddam A, Kim E, Seiffert-Sinha K, Leiker M, et al.
bioRxiv . 2024 May; PMID: 38766211
Binding of autoantibodies to keratinocyte surface antigens, primarily desmoglein 3 (Dsg3) of the desmosomal complex, leads to the dissociation of cell-cell adhesion in the blistering disorder pemphigus vulgaris (PV). After...
6.
Sakamoto N, Ito K, Ii S, Conway D, Ueda Y, Nagatomi J
Biomech Model Mechanobiol . 2024 Mar; 23(4):1289-1298. PMID: 38502433
Cellular traction forces are contractile forces that depend on the material/substrate stiffness and play essential roles in sensing mechanical environments and regulating cell morphology and function. Traction forces are primarily...
7.
Shoyer T, Gates E, Cabe J, Urs A, Conway D, Hoffman B
Proc Natl Acad Sci U S A . 2023 Dec; 120(50):e2316456120. PMID: 38055737
The ability of cells to move in a mechanically coupled, coordinated manner, referred to as collective cell migration, is central to many developmental, physiological, and pathophysiological processes. Limited understanding of...
8.
Subramani A, Cui W, Zhang Y, Friman T, Zhao Z, Huang W, et al.
Cells . 2023 Jul; 12(13). PMID: 37443716
The spread of tumor cells and the formation of distant metastasis remain the main causes of mortality in cancer patients. However, the mechanisms governing the release of cells from micro-environmental...
9.
Danielsson B, Abraham B, Mantyla E, Cabe J, Mayer C, Rekonen A, et al.
Nat Commun . 2023 Jun; 14(1):3867. PMID: 37391402
Nuclear lamins have been considered an important structural element of the nucleus. The nuclear lamina is thought both to shield DNA from excessive mechanical forces and to transmit mechanical forces...
10.
Shoyer T, Gates E, Cabe J, Conway D, Hoffman B
bioRxiv . 2023 Jan; PMID: 36711698
Collective cell migration (CCM) plays important roles in development, physiological, and pathological processes. A key feature of CCM is the dynamic mechanical coupling between cells, which enables both long-range coordination...