Daniel A Dumesic
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Explore the profile of Daniel A Dumesic including associated specialties, affiliations and a list of published articles.
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91
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3920
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Recent Articles
1.
Dumesic D, Padmanabhan V, Abbott D
Reproduction
. 2025 Mar;
PMID: 40080428
Polycystic ovary syndrome (PCOS) is a common endocrinopathy of reproductive-aged women characterized by hyperandrogenism, oligo-anovulation and insulin resistance in combination with preferential abdominal fat accumulation. As an ancestral primate trait,...
2.
Dumesic D, Rasouli M, Katz J, Lu G, Dharanipragada D, Turcu A, et al.
J Endocr Soc
. 2024 Sep;
8(11):bvae162.
PMID: 39345868
Context: Adipose steroid metabolism modifies body fat development in polycystic ovary syndrome (PCOS). Objective: To determine whether subcutaneous (SC) abdominal adipose aldo-keto reductase 1C3 (AKR1C3; a marker of testosterone generation)...
3.
Rasouli M, Dumesic D, Singhal V
Curr Opin Endocrinol Diabetes Obes
. 2024 Sep;
31(6):203-209.
PMID: 39253759
Purpose Of Review: The increasing rate of obesity is having an adverse impact on male reproduction. Recent Findings: The negative effect of reactive oxygen species on male reproductive tissues and...
4.
Abbott D, Hutcherson B, Dumesic D
Semin Reprod Med
. 2024 Jun;
42(1):41-48.
PMID: 38908381
Anti-Müllerian hormone (AMH) is an important component within androgen receptor (AR)-regulated pathways governing the hyperandrogenic origin of polycystic ovary syndrome (PCOS). In women with PCOS, granulosa cell AMH overexpression in...
5.
Dumesic D, Abbott D, Chazenbalk G
J Clin Med
. 2023 Oct;
12(19).
PMID: 37834765
Polycystic ovary syndrome (PCOS) is a common endocrinopathy of reproductive-aged women, characterized by hyperandrogenism, oligo-anovulation and insulin resistance and closely linked with preferential abdominal fat accumulation. As an ancestral primate...
6.
Dumesic D, Turcu A, Liu H, Grogan T, Abbott D, Lu G, et al.
J Endocr Soc
. 2023 Jul;
7(8):bvad079.
PMID: 37404244
Context: Ovarian and adrenal steroidogenesis underlie endocrine-metabolic dysfunction in polycystic ovary syndrome (PCOS). Adipocytes express aldo-keto reductase 1C3 and type 1 11β-hydroxysteroid dehydrogenase, which modulate peripheral androgen and cortisol production....
7.
Dumesic D, Winnett C, Lu G, Grogan T, Abbott D, Naik R, et al.
Fertil Steril
. 2022 Nov;
119(1):116-126.
PMID: 36400597
Objective: To examine whether low-dose flutamide administration to normal-weight women with polycystic ovary syndrome (PCOS) reduces abdominal fat deposition, attenuates accelerated lipid accumulation in newly formed adipocytes derived from subcutaneous...
8.
Zhou R, Bruns C, Bird I, Kemnitz J, Dumesic D, Abbott D
Int J Mol Sci
. 2022 Mar;
23(5).
PMID: 35269778
As in women with polycystic ovary syndrome (PCOS), hyperinsulinemia is associated with anovulation in PCOS-like female rhesus monkeys. Insulin sensitizers ameliorate hyperinsulinemia and stimulate ovulatory menstrual cycles in PCOS-like monkeys....
9.
Dumesic D, Padmanabhan V, Chazenbalk G, Abbott D
Reprod Biol Endocrinol
. 2022 Jan;
20(1):12.
PMID: 35012577
As a common endocrinopathy of reproductive-aged women, polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo-anovulation and polycystic ovarian morphology. It is linked with insulin resistance through preferential abdominal fat...
10.
Dumesic D, Tulberg A, McNamara M, Grogan T, Abbott D, Naik R, et al.
J Endocr Soc
. 2021 Oct;
5(11):bvab158.
PMID: 34661039
Context: Increased aldo-keto reductase 1C3 (AKR1C3)-mediated conversion of androstenedione (A4) to testosterone (T) promotes lipid storage in subcutaneous (SC) abdominal adipose in overweight/obese polycystic ovary syndrome (PCOS) women. Objective: This...