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Damon R Asher

Explore the profile of Damon R Asher including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 254
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Recent Articles
1.
Potter R, Moeller I, Khan S, Haegel H, Hollenstein A, Steiner G, et al.
Sci Rep . 2025 Jan; 15(1):4. PMID: 39747998
Delandistrogene moxeparvovec is an rAAVrh74 vector-based gene transfer therapy that delivers a transgene encoding delandistrogene moxeparvovec micro-dystrophin, an engineered, functional form of dystrophin shown to stabilize or slow disease progression...
2.
Mendell J, Muntoni F, McDonald C, Mercuri E, Ciafaloni E, Komaki H, et al.
Nat Med . 2024 Oct; 31(1):332-341. PMID: 39385046
Duchenne muscular dystrophy (DMD) is a rare, X-linked neuromuscular disease caused by pathogenic variants in the DMD gene that result in the absence of functional dystrophin, beginning at birth and...
3.
Goedeker N, Dharia S, Griffin D, Coy J, Truesdale T, Parikh R, et al.
Ther Adv Neurol Disord . 2023 Jan; 16:17562864221149781. PMID: 36710722
Background: Adeno-associated virus (AAV) vectors are a promising platform for transfer of transgenes designed to treat diseases. Pre-existing humoral immunity to these vectors can potentially impact the safety and efficacy...
4.
Asher D, Thapa K, Dharia S, Khan N, Potter R, Rodino-Klapac L, et al.
Expert Opin Biol Ther . 2020 Feb; 20(3):263-274. PMID: 32031420
: The development of adeno-associated virus (AAV) vectors as safe vehicles for delivery of therapeutic genes has been a major milestone in the advancement of gene therapy, enabling a promising...
5.
Wang J, Cerny A, Asher D, Kurt-Jones E, Bronson R, Finberg R
J Virol . 2009 Oct; 84(1):254-60. PMID: 19846534
Coxsackie B viruses (CVB) are enteroviruses that have been associated with a variety of human diseases, including myocarditis. In the present study, we found that MDA5 and its adaptor molecule...
6.
Wang J, Asher D, Chan M, Kurt-Jones E, Finberg R
J Immunol . 2007 Mar; 178(6):3363-7. PMID: 17339429
TLR7 recognizes the genome of ssRNA viruses such as Coxsackievirus B. Because TLR7 is expressed in intracellular compartments, viral RNA must be internalized before its recognition by TLR7. In this...
7.
Asher D, Cerny A, Finberg R
Proc Natl Acad Sci U S A . 2005 Aug; 102(36):12897-902. PMID: 16123123
Viruses rely on attachment to specific cell surface receptors to infect host cells. Selective expression of viral receptors has the potential to attenuate infection of susceptible tissues by redirecting virus...
8.
Asher D, Cerny A, Weiler S, Horner J, Keeler M, Neptune M, et al.
Genesis . 2005 May; 42(2):77-85. PMID: 15864812
The coxsackievirus and adenovirus receptor (CAR) is a transmembrane protein that is known to be a site of viral attachment and entry, but its physiologic functions are undefined. CAR expression...