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Damien Detraux

Explore the profile of Damien Detraux including associated specialties, affiliations and a list of published articles. Areas
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Articles 11
Citations 366
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Recent Articles
1.
Keshri R, Detraux D, Phal A, McCurdy C, Jhajharia S, Chan T, et al.
Front Cell Dev Biol . 2024 Feb; 12:1343106. PMID: 38371924
Tissue repair is significantly compromised in the aging human body resulting in critical disease conditions (such as myocardial infarction or Alzheimer's disease) and imposing a tremendous burden on global health....
2.
Detraux D, Caruso M, Feller L, Fransolet M, Meurant S, Mathieu J, et al.
Elife . 2023 Jul; 12. PMID: 37428012
Using embryonic stem cells (ESCs) in regenerative medicine or in disease modeling requires a complete understanding of these cells. Two main distinct developmental states of ESCs have been stabilized in...
3.
Caruso M, Meurant S, Detraux D, Mathieu A, Gilson M, Dieu M, et al.
Stem Cell Reports . 2022 Dec; 18(1):254-268. PMID: 36563686
Translational regulation is of paramount importance for proteome remodeling during stem cell differentiation at both the global and the transcript-specific levels. In this study, we characterized translational remodeling during hepatogenic...
4.
Detraux D, Renard P
Metabolites . 2022 Jul; 12(7). PMID: 35888775
Pluripotent cells have been stabilized from pre- and post-implantation blastocysts, representing respectively naïve and primed stages of embryonic stem cells (ESCs) with distinct epigenetic, metabolic and transcriptomic features. Beside these...
5.
Miklas J, Clark E, Levy S, Detraux D, Leonard A, Beussman K, et al.
Nat Commun . 2020 May; 11(1):2387. PMID: 32385292
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
6.
Wang Y, Hussein A, Somasundaram L, Sankar R, Detraux D, Mathieu J, et al.
Int J Mol Sci . 2019 Nov; 20(23). PMID: 31766734
microRNAs are ~22bp nucleotide non-coding RNAs that play important roles in the post-transcriptional regulation of gene expression. Many studies have established that microRNAs are important for cell fate choices, including...
7.
Miklas J, Clark E, Levy S, Detraux D, Leonard A, Beussman K, et al.
Nat Commun . 2019 Oct; 10(1):4671. PMID: 31604922
Mitochondrial trifunctional protein deficiency, due to mutations in hydratase subunit A (HADHA), results in sudden infant death syndrome with no cure. To reveal the disease etiology, we generated stem cell-derived...
8.
Macrin D, Alghadeer A, Zhao Y, Miklas J, Hussein A, Detraux D, et al.
Sci Rep . 2019 Feb; 9(1):2195. PMID: 30778087
Tissue resident adult stem cells are known to participate in tissue regeneration and repair that follows cell turnover, or injury. It has been well established that aging impedes the regeneration...
9.
Ferreccio A, Mathieu J, Detraux D, Somasundaram L, Cavanaugh C, Sopher B, et al.
Cell Cycle . 2018 Feb; 17(5):535-549. PMID: 29466914
To easily edit the genome of naïve human embryonic stem cells (hESC), we introduced a dual cassette encoding an inducible Cas9 into the AAVS1 site of naïve hESC (iCas9). The...
10.
Moody J, Levy S, Mathieu J, Xing Y, Kim W, Dong C, et al.
Proc Natl Acad Sci U S A . 2017 Sep; 114(38):10125-10130. PMID: 28864533
The polycomb repressive complex 2 (PRC2) histone methyltransferase plays a central role in epigenetic regulation in development and in cancer, and hence to interrogate its role in a specific developmental...