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Damian T Rieke

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Articles 22
Citations 523
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Recent Articles
1.
Qi C, Shen L, Andre T, Chung H, Cannon T, Garralda E, et al.
Eur J Cancer . 2025 Mar; 220:115338. PMID: 40068370
Background: Larotrectinib is the first-in-class, highly selective TRK inhibitor with demonstrated efficacy in various TRK fusion solid tumours. We report the efficacy and safety of larotrectinib in patients with TRK...
2.
Rieke D, Bitzer M, Bleckmann A, Desuki A, Ernst T, Esposito I, et al.
Eur J Cancer . 2025 Mar; 220:115331. PMID: 40058270
Precision oncology is a multi-step process including patient selection, tumor profiling, molecular tumor board discussion and personalized cancer management. So far, it remains largely unstandardized. The implementation of precision oncology...
3.
Eich M, Furlano K, Hilfenhaus G, Ralla B, Keilholz U, Joosten M, et al.
Urol Case Rep . 2024 Nov; 57:102879. PMID: 39583332
We present the rare case of a 51-year-old male diagnosed with a solitary fibrous tumor (SFT) of the prostate, along with a concurrent low-grade prostate adenocarcinoma (Gleason score 3 + ...
4.
Habringer S, Ihlow J, Kleo K, Klostermann A, Schmidt M, Chai L, et al.
Oncologist . 2024 Jun; 29(10):908-912. PMID: 38886160
A patient with gastrointestinal stroma tumor (GIST) and KIT p.V559D and BRAF p.G469A alterations was referred to our institutional molecular tumor board (MTB) to discuss therapeutic implications. The patient had...
5.
Rieke D, Schmalbrock L, Ihlow J, Kleo K, von Brunneck A, Nolte F, et al.
Case Rep Hematol . 2024 Jan; 2024:3502887. PMID: 38213502
Systemic mastocytosis is defined by the clonal proliferation of abnormal mast cells. The clinical course can range from indolent forms with normal life expectancy to advanced mast cell leukemia with...
6.
Benary M, Wang X, Schmidt M, Soll D, Hilfenhaus G, Nassir M, et al.
JAMA Netw Open . 2023 Nov; 6(11):e2343689. PMID: 37976064
Importance: Clinical interpretation of complex biomarkers for precision oncology currently requires manual investigations of previous studies and databases. Conversational large language models (LLMs) might be beneficial as automated tools for...
7.
de Bortoli T, Benary M, Horak P, Lamping M, Stintzing S, Tinhofer I, et al.
Eur J Cancer . 2023 Aug; 190:112925. PMID: 37544709
Background: The impact of tumour mutational burden (TMB) on outcome with molecularly matched therapy is unknown. Higher TMB could predict resistance to molecularly matched therapy through co-occurring driver mutations. Methods:...
8.
Rieke D, Schroder S, Schafhausen P, Blanc E, Zuljan E, von der Emde B, et al.
Front Oncol . 2023 Jul; 13:1107134. PMID: 37427101
Background And Purpose: A subgroup of salivary duct carcinoma (SDC) harbor overexpression of the androgen receptor (AR), and co-occurring mutations in the - and -genes. The impact of genomic complexity...
9.
Krysiak K, Danos A, Saliba J, McMichael J, Coffman A, Kiwala S, et al.
Nucleic Acids Res . 2022 Nov; 51(D1):D1230-D1241. PMID: 36373660
CIViC (Clinical Interpretation of Variants in Cancer; civicdb.org) is a crowd-sourced, public domain knowledgebase composed of literature-derived evidence characterizing the clinical utility of cancer variants. As clinical sequencing becomes more...
10.
Rieke D, de Bortoli T, Horak P, Lamping M, Benary M, Jelas I, et al.
BMC Med . 2022 Oct; 20(1):367. PMID: 36274133
Background: Structured and harmonized implementation of molecular tumor boards (MTB) for the clinical interpretation of molecular data presents a current challenge for precision oncology. Heterogeneity in the interpretation of molecular...