Damian E Bikiel
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Explore the profile of Damian E Bikiel including associated specialties, affiliations and a list of published articles.
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19
Citations
191
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Recent Articles
1.
Sun G, Arango-Argoty G, Doherty G, Bikiel D, Pavlovic D, Chen A, et al.
iScience
. 2024 Sep;
27(9):110634.
PMID: 39246446
System-level patient health signals, as captured by treatment-emergent adverse events (TEAEs), might contain correlates of immune checkpoint inhibitor (ICI) therapy response. Using all TEAEs and a novel machine learning modeling...
2.
Neuman N, Venancio M, Rocha W, Bikiel D, Suarez S, Doctorovich F
Inorg Chem
. 2021 Aug;
60(21):15997-16007.
PMID: 34450017
The chemical reactivity of NO and its role in several biological processes seem well established. Despite this, the chemical reduction of NO toward HNO has been historically discarded, mainly because...
3.
Suarez S, Munoz M, Alvarez L, Venancio M, Rocha W, Bikiel D, et al.
J Am Chem Soc
. 2017 Sep;
139(41):14483-14487.
PMID: 28926245
Azanone (nitroxyl, HNO) is a highly reactive compound whose biological role is still a matter of debate. One possible route for its formation is NO reduction by biological reductants. These...
4.
Suarez S, Neuman N, Munoz M, Alvarez L, Bikiel D, Brondino C, et al.
J Am Chem Soc
. 2015 Mar;
137(14):4720-7.
PMID: 25773518
The role of NO in biology is well established. However, an increasing body of evidence suggests that azanone (HNO), could also be involved in biological processes, some of which are...
5.
Doctorovich F, Bikiel D, Pellegrino J, Suarez S, Marti M
Acc Chem Res
. 2014 Sep;
47(10):2907-16.
PMID: 25238532
Azanone ((1)HNO, nitroxyl) shows interesting yet poorly understood chemical and biological effects. HNO has some overlapping properties with nitric oxide (NO), sharing its biological reactivity toward heme proteins, thiols, and...
6.
Alvarez L, Suarez S, Bikiel D, Reboucas J, Batinic-Haberle I, Marti M, et al.
Inorg Chem
. 2014 Jul;
53(14):7351-60.
PMID: 25001488
Azanone ((1)HNO, nitroxyl) is a highly reactive molecule with interesting chemical and biological properties. Like nitric oxide (NO), its main biologically related targets are oxygen, thiols, and metalloproteins, particularly heme...
7.
Suarez S, Bikiel D, Wetzler D, Marti M, Doctorovich F
Anal Chem
. 2013 Aug;
85(21):10262-9.
PMID: 23952708
Azanone (HNO, nitroxyl) is a highly reactive and short-lived compound with intriguing and highly relevant properties. It has been proposed to be a reaction intermediate in several chemical reactions and...
8.
Capece L, Boechi L, Perissinotti L, Arroyo-Manez P, Bikiel D, Smulevich G, et al.
Biochim Biophys Acta
. 2013 Mar;
1834(9):1722-38.
PMID: 23470499
In this work we review the application of classical and quantum-mechanical atomistic computer simulation tools to the investigation of small ligand interaction with globins. In the first part, studies of...
9.
Sirsalmath K, Suarez S, Bikiel D, Doctorovich F
J Inorg Biochem
. 2012 Nov;
118:134-9.
PMID: 23141500
A group of Piloty's acid (N-hydroxybenzenesulfonamide) derivatives were synthesized and fully characterized in order to assess the rates and pH of HNO (azanone, nitroxyl) donation in aqueous media. The derivatives,...
10.
Bikiel D, Gonzalez Solveyra E, Di Salvo F, Milagre H, Eberlin M, Correa R, et al.
Inorg Chem
. 2011 Feb;
50(6):2334-45.
PMID: 21322575
A new family of compounds is presented as potential carbon monoxide releasing molecules (CORMs). These compounds, based on tetrachlorocarbonyliridate(III) derivatives, were synthesized and fully characterized by X-ray diffraction, electrospray mass...