Dalong Qian
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Explore the profile of Dalong Qian including associated specialties, affiliations and a list of published articles.
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25
Citations
5033
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Recent Articles
1.
Matsubara J, Li Y, Koul S, Mukohyama J, Salazar L, Isobe T, et al.
bioRxiv
. 2025 Feb;
PMID: 39896677
Background: (CRCs) are seldom eradicated by cytotoxic chemotherapy. Cancer cells with stem-like functional properties, often referred to as "" (CSCs), display preferential resistance to several anti-tumor agents used in cancer...
2.
Sikandar S, Gulati G, Antony J, Fetter I, Kuo A, Ho W, et al.
Sci Adv
. 2022 Nov;
8(45):eabm3548.
PMID: 36351009
Metastasis is responsible for most breast cancer-related deaths; however, identifying the cellular determinants of metastasis has remained challenging. Here, we identified a minority population of immature / tumor epithelial cells...
3.
van Weele L, Djomehri S, Cai S, Antony J, Sikandar S, Qian D, et al.
Mol Oncol
. 2022 Apr;
16(17):3128-3145.
PMID: 35398967
As precision medicine increases the response rate of treatment, tumors frequently bypass inhibition, and reoccur. In order for treatment to be effective long term, the mechanisms enabling treatment adaptation need...
4.
Reinitz F, Chen E, di Robilant B, Chuluun B, Antony J, Jones R, et al.
Elife
. 2022 Mar;
11.
PMID: 35311644
Alzheimer's disease (AD) is a progressive neurodegenerative disease observed with aging that represents the most common form of dementia. To date, therapies targeting end-stage disease plaques, tangles, or inflammation have...
5.
Hisamori S, Mukohyama J, Koul S, Hayashi T, Rothenberg M, Maeda M, et al.
J Gastroenterol
. 2022 Mar;
57(6):407-422.
PMID: 35244768
Background: MicroRNAs (miRNAs) are key regulators of stem cell functions, including self-renewal and differentiation. In this study, we aimed to identify miRNAs that are upregulated during terminal differentiation in the...
6.
van Weele L, Scheeren F, Cai S, Kuo A, Qian D, Ho W, et al.
Stem Cell Reports
. 2021 Jan;
16(2):228-236.
PMID: 33482103
The mammary epithelium undergoes several rounds of extensive proliferation during the female reproductive cycle. Its expansion is a tightly regulated process, fueled by the mammary stem cells and these cells'...
7.
Zabala M, Lobo N, Antony J, Heitink L, Gulati G, Lam J, et al.
Cell Stem Cell
. 2020 Jul;
27(2):284-299.e8.
PMID: 32693087
SMAD pathways govern epithelial proliferation, and transforming growth factor β (TGF-β and BMP signaling through SMAD members has distinct effects on mammary development and homeostasis. Here, we show that LEFTY1,...
8.
Gulati G, Sikandar S, Wesche D, Manjunath A, Bharadwaj A, Berger M, et al.
Science
. 2020 Jan;
367(6476):405-411.
PMID: 31974247
Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular differentiation trajectories. However, inferring both the state and direction of differentiation is challenging. Here, we demonstrate a simple, yet...
9.
Lobo N, Zabala M, Qian D, Clarke M
Breast Cancer Res
. 2018 Oct;
20(1):121.
PMID: 30305179
Background: Recent studies in murine mammary tissue have identified functionally distinct cell populations that may be isolated by surface phenotype or lineage tracing. Previous groups have shown that CD24CD49f cells...
10.
Sikandar S, Kuo A, Kalisky T, Cai S, Zabala M, Hsieh R, et al.
Nat Commun
. 2017 Nov;
8(1):1669.
PMID: 29162812
Previous studies have proposed that epithelial to mesenchymal transition (EMT) in breast cancer cells regulates metastasis, stem cell properties and chemo-resistance; most studies were based on in vitro culture of...