Dalia El-Gamal
Overview
Explore the profile of Dalia El-Gamal including associated specialties, affiliations and a list of published articles.
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28
Citations
493
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Recent Articles
1.
Schmitz E, Ridout A, Smith A, Eiken A, Skupa S, Drengler E, et al.
Biomedicines
. 2025 Jan;
12(12.
PMID: 39767763
Targeted therapies (e.g., ibrutinib) have markedly improved chronic lymphocytic leukemia (CLL) management; however, ~20% of patients experience disease relapse, suggesting the inadequate depth and durability of these front-line strategies. Moreover,...
2.
Lone W, Bouska A, Herek T, Amador C, Song J, Xu A, et al.
Am J Hematol
. 2024 Nov;
100(1):10-22.
PMID: 39548807
High-grade B-cell lymphoma not otherwise specified (HGBCL, NOS) has overlapping morphological and genetic features with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL), leading to uncertainty in its diagnosis...
3.
Eiken A, Schmitz E, Drengler E, Smith A, Skupa S, Mohan K, et al.
Hemato
. 2024 Oct;
5(3):321-339.
PMID: 39450301
Background: B-cell receptor (BCR) signaling is a central driver in chronic lymphocytic leukemia (CLL), along with the activation of pro-survival pathways (e.g., NF-κB) and aberrant anti-apoptotic mechanisms (e.g., BCL2) culminating...
4.
Zablonski K, Skupa S, Eiken A, Sundaram S, Mavis C, Gu J, et al.
Leuk Lymphoma
. 2024 Sep;
65(14):2129-2137.
PMID: 39331474
Chronic lymphocytic leukemia (CLL) remains incurable and its ability to acquire resistance to front-line therapeutics has proved challenging. Bromodomain and extra-terminal proteins, particularly bromodomain-containing protein 4 (BRD4), are integral to...
5.
Mahr A, Bennett-Boehm M, Rothemejer F, Weber I, Regan A, Franzen J, et al.
Sci Rep
. 2024 Jun;
14(1):14595.
PMID: 38918496
There are two known mechanisms by which natural killer (NK) cells recognize and kill diseased targets: (i) direct killing and (ii) antibody-dependent cell-mediated cytotoxicity (ADCC). We investigated an indirect NK...
6.
Smith A, Skupa S, Eiken A, Reznicek T, Schmitz E, Williams N, et al.
JCI Insight
. 2024 May;
9(10).
PMID: 38775157
Redundant tumor microenvironment (TME) immunosuppressive mechanisms and epigenetic maintenance of terminal T cell exhaustion greatly hinder functional antitumor immune responses in chronic lymphocytic leukemia (CLL). Bromodomain and extraterminal (BET) proteins...
7.
Eiken A, Smith A, Skupa S, Schmitz E, Rana S, Singh S, et al.
Cancer Res Commun
. 2024 Apr;
4(5):1328-1343.
PMID: 38687198
Significance: SpiD3 demonstrates cytotoxicity in CLL partially through inhibition of NFκB signaling independent of tumor-supportive stimuli. By inducing the accumulation of unfolded proteins, SpiD3 activates the UPR and hinders protein...
8.
Eiken A, El-Gamal D
Int J Mol Sci
. 2024 Jan;
25(1).
PMID: 38203728
In the era of targeted therapies, researchers have aimed to uncover the molecular drivers of malignant pathogenesis in lymphoid malignancies in an endeavor to develop effective therapeutic strategies [...].
9.
Smith A, Pal D, Martinez-Rico R, Eiken A, Durden D, Kutateladze T, et al.
Leuk Lymphoma
. 2023 Sep;
64(14):2333-2337.
PMID: 37706519
No abstract available.
10.
Banskota S, Skupa S, El-Gamal D, DAngelo C
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36768631
The gut microbiome is increasingly being recognized as an important immunologic environment, with direct links to the host immune system. The scale of the gut microbiome's genomic repertoire extends the...